Results 61 to 70 of about 1,531,875 (388)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Sequence identification and phylogenetic analysis of the mitochondrial genome of Microphysogobio kiatingensis (Cypriniformes: Cyprinidae)

open access: yesMitochondrial DNA. Part B. Resources, 2018
Microphysogobio kiatingensis is endemic freshwater fish of China and mainly distributed in the middle and upper reaches of the Yangtze River. The complete mitogenome of M.
Yuanchao Zou   +4 more
doaj   +1 more source

Prevalence of endoparasite in some commercially important freshwater fishes of Bida area, Niger State: a preliminary report [PDF]

open access: yes, 1999
The result of this preliminary report highlighted prevalence of an endoparasite (nematode) in order of prevalence. Four non-scaly commercially important fishes, namely:- Clarias sp Hererobranchus bidorsalis.
Agbontale, J.J.   +3 more
core  

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

Fishes of the Antoine River, Little Missouri River System, Southwestern Arkansas [PDF]

open access: yes, 1983
The fishes of the Antoine River (Little Missouri River system) in southwestern Arkansas were surveyed from September, 1980 - June, 1982. Thirty-four field collections plus literature and museum records, revealed a total of 60 species in 29 genera ...
Robison, Henry W.   +2 more
core   +18 more sources

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

open access: yesFEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli   +10 more
wiley   +1 more source

Kelp bed variability and fish population dynamics in Kachemak Bay, Alaska [PDF]

open access: yes, 2004
Thesis (M.S.) University of Alaska Fairbanks, 2004Understanding interactions between kelp beds and fishes is essential because anthropogenic changes and natural variability in these beds (composition, density, and distribution) may affect available ...
Hamilton, Judith Ann
core  

Fish hemoglobins [PDF]

open access: yesBrazilian Journal of Medical and Biological Research, 2007
Vertebrate hemoglobin, contained in erythrocytes, is a globular protein with a quaternary structure composed of 4 globin chains (2 alpha and 2 beta) and a prosthetic group named heme bound to each one. Having myoglobin as an ancestor, hemoglobin acquired the capacity to respond to chemical stimuli that modulate its function according to tissue ...
Souza, P. C. de   +1 more
openaire   +7 more sources

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

open access: yesFEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen   +2 more
wiley   +1 more source

An annotated checklist of freshwater fishes of Armenia [PDF]

open access: yes, 2001
A list of freshwater fishes inhabiting lakes, reservoirs and rivers of Armenia is presented which include 39 species and subspecies belonging to 5 orders, 9 families and 29 genera.
Gabrielyan, B.K.
core  

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