Results 111 to 120 of about 388,975 (339)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Status and management of the Java sea fisheries [PDF]

open access: yes
The Java Sea is a major fishing ground in Indonesia contributing 31% of the national marine fisheries production. Demersal and small pelagic fishery resources account for most production in the area.
Purwanto
core  

Marine recreational fisheries statistics survey for northern and central California, Quarterly Report no. 8, April to June, 1981 [PDF]

open access: yes, 1988
Field intercept Marine Recreational Fisheries Statistics Survey (MRFSS) data for central and northern California, collected in April to June 1981, is presented in a data report format.
Karpov, Konstantin A.   +1 more
core  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Socio-economic conditions of selected residents of Apid, Mahaba and Digyo Islands, Inopacan, Leyte, Philippines

open access: yesAnnals of Tropical Research, 1999
This study describes the socio-economic conditions of selected hoseholds in the islands of Apid, Digyo and Mahaba. The data for this study are very limited considering the very short time spent in data collection.
Ma. Salome B. Bulayog   +6 more
doaj  

Optimal Harvesting of Age-structured Fish Populations [PDF]

open access: yes
A generic age-structured model for optimal harvesting is formulated and analyzed. The aim is to maximize utility from the harvest, net of effort cost. Yield depends on effort, catchability, and population age structure.
Tahvonen, Olli
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Socioeconomic assessment of marine fisheries of Thailand [PDF]

open access: yes
Thailand is currently one of the ten largest fishing nations in the world. In 1996, fish production reached 3.7 million t with 90% of the production coming from the marine fisheries sector and 10% from inland fisheries.
Pongpat Boonchuwongse, Waraporn Dechboon
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

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