Results 91 to 100 of about 1,360,631 (252)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
FISHING SKILL IN DEVELOPING COUNTRY FISHERIES: THE KEDAH, MALAYSIA TRAWL FISHERY [PDF]
Fishing skill is perceived to play a crucial role in catching fish. The question arises for fishery managers as to whether or not there are observable and measurable attributes of the skipper or vessel that can be monitored and regulated to account for ...
Omar, Ishak Haji +5 more
core
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
An Analysis of the Utilization of Regional Fishing Ports in the Philippines [PDF]
This paper investigates the issue of underutilization of Philippine regional fishing ports using secondary data from institutional resources and interviews with key informants. Analysis indicates that most of the existing regional ports are underutilized,
Israel, Danilo C.
core +2 more sources
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Jointness through fishing days input in a multi-species Fishery [PDF]
Some multi-species fisheries are characterised by production jointness in the sense that several species are caught through a joint production process (literally in the same haul of the net). Other multi-species fisheries (so called purse seine fisheries)
Carsten Lynge Jensen, Lars Gårn Hansen
core
Maintenance and Update Frequency: none-plannedStatement: The fishing fleet data of 167 countries and dependencies was collected using a combination of FAO data, governmental data, and scientific and grey literature. Data points were separated into sector
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Potential of a trap-fishery for the spiny lobster Palinurus delagoae off eastern South Africa : has the stock recovered? [PDF]
, 2007 Includes bibliographical references (leaves 35-40)An experimental trap fishery for the deep-water lobster spiny lobster Palinurus delagoae commenced in 2004, and was run until 2006.
Boucher, Monique
core +1 more source