Results 71 to 80 of about 389,853 (293)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The influence of fisher knowledge on the susceptibility of reef fish aggregations to fishing.

PLoS ONE, 2014
Reef fishes that exhibit predictable aggregating behaviour are often considered vulnerable to overexploitation. However, fisher knowledge of this behaviour is often heterogeneous and, coupled with socioeconomic factors that constrain demand for or access
Jan Robinson, Joshua E Cinner, Nicholas A J Graham   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

The 1996 U.S. Purse Seine Fishery for Tropical Tunas in the Central-Western Pacific Ocean [PDF]

, 1997
The U.S. tropical tuna purse seine fleet has fished the central-western Pacific Ocean under the South Pacific Tuna Treaty since 1988. The 1996 fishery was the poorest since the start ofthe Treaty.
Coan, Jr. , Atilio L., Prescott, Doug, Sakagawa, Gary T., Yamasaki, Gordon   +3 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Whale-watching and Herring Fishing: Joint or Independent Production? [PDF]

The effects of "localized depletion" of a pelagic fishery (herring) on a non-extractive marine activity (tourism) are investigated. Proponents of the localized depletion theory claim that intense fishing effort can lead to areas that are unsuitable for ...
Lee, Min-Yang A.
core   +1 more source

The Analysis Of Fishing Effort By Scraping Net In Sungai Nyamuk, Sinaboi Sub District, Rokan Hilir Regency Of Riau Province [PDF]

, 2016
Research on the analysis of fishing effort by fishing scraping net, held in April2015 in Sungai Nyamuk, Sinaboi Sub District, Rokan Hilir Regency Of Riau Province.The research of aims to analyze large venture capital investments, and how large ...
Fitriani, F. (Fitriani), Hamid, H. (Hamdi), Yulinda, E. (Eni)   +2 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Monitoring mangrove crab Ucides cordatus Linnaeus, 1763 (Crustacea: Ucididae) landing in the Parnaíba River Delta: fishing characteristics, social and economic aspects

Nauplius, 2018
The century-old mangrove crab Ucides cordatus Linnaeus, 1763 harvesting is a traditional activity of Northeastern Brazilian coastal communities, who use it as food, source of income and cultural reference.
Fabiola Helena dos Santos Fogaça, Lissandra Corrêa Fernandes-Góes, Liliana Oliveira Souza, Kesley Paiva da Silva, João Marcos de Góes, Alitiene Moura Lemos Pereira, Monica Giacometti Mai, João Avelar Magalhães   +7 more
doaj   +1 more source