Results 71 to 80 of about 388,975 (339)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Livelihood features of small scale fishing communities : A case from Singkarak Lake, west Sumatra Indonesia [PDF]
, 2010 While millions of poor still depend on small scale freshwater fisheries to earn a meager leaving, the sector shows overall decline in catches over recent years throughout South East Asia. Among few other causes, overfishing is often pointed out as a main
Perret, Sylvain, Yuerlita,
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Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Nauplius, 2018 The century-old mangrove crab Ucides cordatus Linnaeus, 1763 harvesting is a traditional activity of Northeastern Brazilian coastal communities, who use it as food, source of income and cultural reference.
Fabiola Helena dos Santos Fogaça +7 more
doaj +1 more source
Whale-watching and Herring Fishing: Joint or Independent Production? [PDF]
The effects of "localized depletion" of a pelagic fishery (herring) on a non-extractive marine activity (tourism) are investigated. Proponents of the localized depletion theory claim that intense fishing effort can lead to areas that are unsuitable for ...
Lee, Min-Yang A.
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Trends and Environmental Drivers of Marine Fish Landings in Cuba’s Most Productive Shelf Area
FishesMarine finfish landings in Cuba have decreased during the last 30 years. However, in Cuba’s most productive fishing region, certain species, including rays, herrings, and snappers, have had increased landings over the past decade. Despite these anomalies,
Yunier Olivera-Espinosa +6 more
doaj +1 more source
Status of demersal fishery resources in the Gulf of Thailand [PDF]
Data from trawl surveys (1961 - 95) and annual production statistics (1971 - 95) were used to examine the status of demersal fishery resources in the Gulf of Thailand.
Amnuay Kongprom +3 more
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