Results 111 to 120 of about 64,329 (290)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Estimation of the Recreational Use Value Gained from Recreational Fishing of Southern Bluefin Tuna at Portland, Australia [PDF]

Southern bluefin tuna (Thunnus Maccoyii) is a global resource which is critically endangered. The Committee for the Conservation of Southern Bluefin Tuna (CCSBT) sets commercial quota levels for member nations, including Australia, each year.
Scarborough, Helen, Ezzy, Edward
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Status Identification in Support of Fishing Effort Estimation for Tuna Longliners in Waters near the Marshall Islands Based on AIS Data

Fishes
Visualising the fishing behaviour of vessels and quantifying the spatial distribution of fishing effort is the scientific basis for assessing and managing fisheries resources.
Zhengwei Lu, Liming Song, Keji Jiang
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Spatiotemporal Analysis of Light Purse Seine Fishing Vessel Operations in the Arabian High Seas Based on Automatic Identification System Data

Applied Sciences
Understanding the dynamic spatial distribution and characteristics of fishing activities is crucial for fisheries management and sustainable development.
Shenglong Yang, Linlin Yu, Keji Jiang, Xiumei Fan, Lijun Wan, Wei Fan, Heng Zhang   +6 more
doaj   +1 more source

The role of fisheries sector in the coastal fishing communities of Sri Lanka [PDF]

Sri Lanka is an island country with a land area of 65 610 km2. With the declaration of the exclusive economic zone (EEZ) in 1976, the country gained sovereign rights over an ocean area of 536 000 km2 and EEZ extending from 24 to 200 nm.
Maldeniya, R., Wijayaratne, B.
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

WILLINGNESS TO PARTICIPATE AND BIDS IN A FISHING VESSEL BUYOUT PROGRAM: A CASE STUDY OF NEW ENGLAND GROUNDFISH [PDF]

An experimental fishing vessel buyout program was initiated in 1995 to remove vessels from the Northeast United States groundfish fishery. Information provided by the applicants to this program was used to evaluate the likely participation and potential ...
Robertson, John, Thunberg, Eric M., Kitts, Andrew   +2 more
core   +1 more source