Results 91 to 100 of about 375,001 (340)

PFKM‐Driven Lactate Overproduction Promotes Atrial Fibrillation via Triggering Cardiac Fibroblasts Histone Lactylation

open access: yesAdvanced Science, EarlyView.
The upregulation of PFKM activates glycolysis, thereby enhancing lactate production in atrial tissue. Atrial lactate accumulation promotes global lactylation and H3K18 lactylation in atrial fibroblasts. P300‐mediated H3K18 lactylation up‐regulates TGF‐β1 transcription, leading to fibroblast activation and thereby contributing to atrial fibrosis.
Ning Fang   +15 more
wiley   +1 more source

Tanzania: In their own words: Poor women and health services. [PDF]

open access: yes, 2004
"In Their Own Words: Poor Women And Health Services" highlights critical constraints that poor women experience in accessing health services, including the challenges they face and the strategies they use to overcome them. This summary report is meant to
Women's Dignity Project/Utu Mwanamke, (WDP)
core  

Photo‐Rechargeable Organic Supercapacitor via Light‐Activated Electrolytes

open access: yesAdvanced Science, EarlyView.
A photo‐rechargeable organic supercapacitor device is fabricated comprising activated charcoal electrodes and 2‐nitrobenzaldehyde as the electrolyte. The operation principle of the device relies on the photoinduced transformation of 2‐nitrobenzaldehyde into electrochemically active benzoic acid derivatives.
Shubhra Kanti Bhaumik   +4 more
wiley   +1 more source

The role of posterior aortopexy in the treatment of left mainstem bronchus compression [PDF]

open access: yes, 2016
OBJECTIVES: We reviewed the role of posterior aortopexy for left mainstem bronchus compression in infants and children. METHODS: Eighteen children with respiratory symptoms were enrolled between 2005 and 2015 for surgical decompression of the left ...
Arcieri, Luigi   +9 more
core   +1 more source

CD74 Blockade Disrupts Endothelial Migrasome Signaling to Prevent Inflammatory Macrophage Differentiation and Inhibit Atherosclerotic Progression

open access: yesAdvanced Science, EarlyView.
Migrasomes play a crucial role in endothelial‐immune interactions in atherosclerosis. This study identifies migrasomes as amplifiers in the inflammatory cascade, driving immune‐metabolic reprogramming via “migrasome‐APP‐CD74” signaling. Blocking CD74 disrupts migrasome‐mediated signaling, attenuating atherosclerosis progression.
Kangnan Zhang   +10 more
wiley   +1 more source

Sustained‐Release Photothermal Microneedles for Postoperative Incisional Analgesia and Wound Healing via Hydrogen Therapy

open access: yesAdvanced Science, EarlyView.
This study introduces a novel transdermal delivery system of molecular hydrogen for postoperative pain relief and wound healing. This system utilizes sustained‐release photothermal microneedles to integrate hydrogen‐releasing nanoparticles and temperature‐responsive microspheres, achieving acid‐responsive hydrogen release and controlled drug release ...
Aining Zhang   +8 more
wiley   +1 more source

Tracheocutaneous fistula in patients undergoing supracricoid partial laryngectomy: the role of chronic aspiration [PDF]

open access: yes, 2015
The aim of the present retrospective controlled study was to analyse and compare risk factors for tracheocutaneous fistula in patients who received tracheostomy after supracricoid partial laryngectomy with those who received tracheostomy for other causes.
Calcagno, P   +8 more
core  

Ambulatory surgery for perianal Crohn’s disease. Study of feasibility [PDF]

open access: yes, 2018
Background. One-third of Crohn’s disease (CD) patients present perianal fistula. The gold standard in the diagnosis and treatment of symptomatic perianal disease (PAD) in CD is the exploration of the anal canal and distal rectum under anesthesia (EUA ...
Arcudi, C.   +10 more
core   +2 more sources

In Situ Programming of the Tumor Microenvironment to Alleviate Immunosuppression for Pancreatic Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
cmExoaCD11b induced the repolarization of immunosuppressive M2 macrophages into pro‐inflammatory M1 phenotype, thereby promoting the proliferation and activation of CD8+ T cells and reversing the immunosuppressive state of the tumor microenvironment.
Man Sun   +14 more
wiley   +1 more source

Acquired Palatal Fistula in Patients with Submucous and Incomplete Cleft Palate before Surgery

open access: yesArchives of Plastic Surgery, 2016
It is uncommon for a palatal fistula to be detected in individuals who have not undergone surgery, and only sporadic cases have been reported. It is even more difficult to find cases of acquired palatal fistula in patients with submucous or incomplete ...
Ie Hyon Park   +4 more
doaj   +1 more source

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