Results 81 to 90 of about 83,238,223 (252)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Circular economy business models for reclaimed water: Insights from the Baltic Sea Region
Desalination and Water TreatmentBesides technological advancements in wastewater treatment, business and market strategies are needed to facilitate the adaptation of water reuse. This study aims to conceptualize the value proposition and business models for water reuse in the Baltic ...
Mateusz Skalny, Marzena Smol
doaj +1 more source
[Status of the Kansas Water Marketing Program and the Kansas Water Assurance Program]
, 2002 application/pdf; Title supplied by cataloger.; "The purpose of the water marketing program is to develop adequate water supply storage to meet, as nearly as practicable, present and anticipated municipal and industrial water needs through the purchase of
Kansas Water Office.
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Availability, Practices and Microbiological quality of drinking water among rural households of Belagavi, North Karnataka [PDF]
Al Ameen Journal of Medical SciencesIntroduction: World Health Organisation (WHO) Global Report 2022 on Water, Sanitation & Hygiene (WASH) reported that 6 billion people had access to safely managed and improved drinking water source and 1.7 billion people had an access to contaminated ...
N.S. Manimaran +4 more
doaj
, 1993 [Revised].; "January 1993.""The purpose of the water marketing program is to develop adequate water supply storage to meet, as nearly as practicable, present and anticipated municipal and industrial water needs through the purchase of water supply ...
Kansas Water Office.
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Natural and Anthropogenic Sources of Groundwater Salinization in Parts of Karachi, Pakistan
International Journal of Economic and Environment Geology, 2019 This study is aimed to evaluate the groundwater quality of Gulshan-e-Iqbal and Liaquatabad towns in Karachi. Thirty (n=30) groundwater samples were randomly collected from different locations by electrically pumped wells at various depths (14-91m). All
Sanober Rafi, Owais Niaz, Sadaf Naseem, Umair Majeed, Humaira Naz
doaj
Water in the 2005 Virginia General Assembly
, 2005 The 2005 Virginia General Assembly convened January 12 and adjourned February 27, with a reconvened (“veto”) session on April 6. The legislature considered 3363 measures (2938 introduced this year and 425 carried over from last year); 1610 measures ...
Virginia Water Resources Research Center
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source