Results 151 to 160 of about 82,231,178 (266)

Assessing the Carcinogenic Potential of Jet Fuels: A Fit-for-Purpose Systematic Literature Review. [PDF]

J Occup Environ Med
Heitz ER, Allen BD, Goodman SJ, Freedman AN, Miller SL, Snow SJ, Eftim SE, Haver CE, Weinberger KR, Bergeron JG, Vincent-Hall TD.   +10 more
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Patient-centred and fit-for-purpose clinical trials in rare cancers: lessons from sarcomas for operationalising 2024 WHO Guidance and ICH E6(R3). [PDF]

EClinicalMedicine
Gonzato O, Reinke D, Wilson R, Kasper B, Ruiz Alvarez MJ.   +4 more
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

ASO Author Reflections: Physical Functioning in Patients with Sarcoma After Amputation: Are Current Questionnaires Fit for Purpose? [PDF]

Ann Surg Oncol
Bootsma TI, Husson O.
europepmc   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Advancing drug development with "Fit-for-Purpose" modeling informed approaches. [PDF]

J Pharmacokinet Pharmacodyn
Sheng J, Zhang T.
europepmc   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Reconceptualising transnational governance: making global institutions fit for purpose

Economics: Journal Articles, 2017
Seán Cleary
doaj   +2 more sources

Device-Detected Atrial Fibrillation: Why Time-Based Thresholds Are No Longer Fit for Purpose. [PDF]

J Clin Med
El-Medany A.
europepmc   +1 more source