Results 161 to 170 of about 59,495,041 (290)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Editorial: Complaints mechanisms in research: are they fit for purpose?

Research Ethics Review, 2022
Kate Chatfield
doaj   +1 more source

Fit for purpose: German contributions to the new ICRP recommendations. [PDF]

Radiat Environ Biophys
Birschwilks M, Azimzadeh O, Scholz-Kreisel P, Eidemüller M, Moertl S, Breustedt B, Li WB, Gruß M, Werner C, Steiner M, Gerstmann U, Woda C, Vogt J, Gering F, Winter KS, Mille EB, Giussani A, Akbarian GS, Pölzl-Viol C.   +18 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Designer Spotlight: Patrick Kelly

The Museum at FIT presents its Designer Spotlight series where MFIT curators explore objects in our permanent collection that highlight a specific designer's work and contributions to fashion.Born in Mississippi in 1954, Patrick Kelly moved to Paris in ...

core  

Assessing the Carcinogenic Potential of Jet Fuels: A Fit-for-Purpose Systematic Literature Review. [PDF]

J Occup Environ Med
Heitz ER, Allen BD, Goodman SJ, Freedman AN, Miller SL, Snow SJ, Eftim SE, Haver CE, Weinberger KR, Bergeron JG, Vincent-Hall TD.   +10 more
europepmc   +1 more source

Fit for purpose [PDF]

Nature, 2014
openaire   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

ASO Author Reflections: Physical Functioning in Patients with Sarcoma After Amputation: Are Current Questionnaires Fit for Purpose? [PDF]

Ann Surg Oncol
Bootsma TI, Husson O.
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source