Results 161 to 170 of about 82,231,178 (266)

Ensuring the workforce is fit for purpose [PDF]

International Journal of Pharmacy Practice, 2020
openaire   +2 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Accessories 1800-1900: Part One

The Museum at FIT presents “Accessories 1800–1900,” part one of a two-part introduction to the history of Western women’s fashion accessories. These two videos provide an historical overview for high school students interested in enrolling in FIT's ...

core  

Jet Fuel Effects on Hepatic and Renal Health: A Fit-for-Purpose Systematic Literature Review. [PDF]

J Occup Environ Med
Kotulkar M, Prince LM, Freedman AN, Kolanowski A, Lundin M, Starnes HM, Goodman SJ, Vidal J, Buerk H, Gillera SEA, Tucker NN, Renda RP, Payne LE, Hall SM, Jean-François L, Sprowles JLN, Weinberger KR, Snow SJ, Eftim SE, Haver CE, Bergeron JG, Vincent-Hall TD.   +21 more
europepmc   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Designer Spotlight: Patrick Kelly

The Museum at FIT presents its Designer Spotlight series where MFIT curators explore objects in our permanent collection that highlight a specific designer's work and contributions to fashion.Born in Mississippi in 1954, Patrick Kelly moved to Paris in ...

core  

Immunogenicity assays are biomarker assays: is the 3-tiered paradigm fit-for-purpose? An illustrative case study. [PDF]

Bioanalysis
Stevenson LF.
europepmc   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Patient-Focused Drug Development in Kidney Disease: Including Fit-for-Purpose Outcomes in Trials. [PDF]

J Am Soc Nephrol
Peipert JD, Oni L, Aiyegbusi OL, Anderson N, Calvert M, Calvert M, Damashek L, Thomas L, Trachtman H, Trachtman H, Salmon E.   +10 more
europepmc   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source