Results 191 to 200 of about 628,555 (328)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Fit-for-Purpose Land Administration [PDF]

, 2014
Clifford Bell, Keith, Enemark, Stig, Lemmen, Christiaan, McLaren, Robin   +3 more
core  

The knowledge system underpinning healthcare is not fit for purpose and must change. [PDF]

, 2015
Beecher, Deirdre, Edwards, Phil, Ker, Katharine, Manno, Daniela, Roberts, Ian, Sydenham, Emma   +5 more
core   +1 more source

Are childcare settings' food menus fit for purpose? A qualitative analysis in England. [PDF]

Health Promot Int
Warren E, Williams L, Exley J, Boadu P, Erens B, Brackley D, Osborne R, Knai C.   +7 more
europepmc   +1 more source

Fit for purpose [PDF]

Nature, 2014
openaire   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Health Effects Associated With Jet Fuel Exposure: Methods for a Fit-for-Purpose Systematic Review and Systematic Evidence Map. [PDF]

J Occup Environ Med
Bergeron JG, Cameron RL, Goodman SJ, Sprowles JLN, Snow SJ, Eftim SE, Haver CE, Vincent-Hall TD.   +7 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Reconceptualising transnational governance: making global institutions fit for purpose

Economics: Journal Articles, 2017
Seán Cleary
doaj   +2 more sources

The Effects of Jet Fuel Exposure on the Innate and Adaptive Immune Systems: A Fit-for-Purpose Systematic Literature Review. [PDF]

J Occup Environ Med
Bowers EC, Vidal J, Freedman AN, Martin EM, Tucker NN, Hannani AK, Kolanowski A, Buerk H, Goodman SJ, Lindahl AJ, Sprowles JLN, Snow SJ, Eftim SE, Haver CE, Vincent-Hall TD.   +14 more
europepmc   +1 more source