Results 191 to 200 of about 59,495,041 (290)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Designer Spotlight: Charles James

The Museum at FIT presents its Designer Spotlight series where MFIT curators explore objects in our permanent collection that highlight a specific designer's work and their contributions to fashion.Charles James was a designer’s designer.

core  

The Effects of Jet Fuel Exposure on the Innate and Adaptive Immune Systems: A Fit-for-Purpose Systematic Literature Review. [PDF]

J Occup Environ Med
Bowers EC, Vidal J, Freedman AN, Martin EM, Tucker NN, Hannani AK, Kolanowski A, Buerk H, Goodman SJ, Lindahl AJ, Sprowles JLN, Snow SJ, Eftim SE, Haver CE, Vincent-Hall TD.   +14 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Exhibition Video: Pink: The History of a Punk, Pretty, Powerful Color

Curated by Dr. Valerie Steele, director of The Museum at FIT, "Pink: The History of a Punk, Pretty, Powerful Color" (September 7, 2018 – January 5, 2019) explores the changing significance of the color pink over the past three centuries.In this video, Dr.

core  

ToxPoint: Of hammers and nails-understanding academic challenges with "context of use" and "fit for purpose". [PDF]

Toxicol Sci
Rusyn I.
europepmc   +1 more source

Ensuring the workforce is fit for purpose [PDF]

International Journal of Pharmacy Practice, 2020
openaire   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Fit-for-purpose Psychological Interventions to Support the Well-Being of Autistic Adults: A Systematic Review. [PDF]

Autism Dev Lang Impair
Deakin M, Hamilton LG, Heasman B, Petty S.   +3 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source