Results 201 to 210 of about 628,555 (328)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Understanding the Neurologic and Cognitive and Behavioral Effects Associated With Exposures to Jet Fuels: A Fit-for-Purpose Systematic Literature Review. [PDF]

J Occup Environ Med
Sprowles JLN, Allen BD, Lindahl AJ, Prince LM, Bowers EC, Martin EM, Kolanowski A, Lundin M, Goodman SJ, Starnes HM, Gillera SEA, Snow SJ, Eftim SE, Haver CE, Robertson M, Vincent-Hall TD.   +15 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Building Fit-For-Purpose Land Administration Systems:Guiding Principles [PDF]

, 2016
Enemark, Stig, Lemmen, Christiaan, McLaren, Robin   +2 more
core   +2 more sources

Understanding the Endocrine and Reproductive Health Effects Associated With Exposures to Jet Fuels: A Fit-for-Purpose Systematic Literature Review. [PDF]

J Occup Environ Med
Prince LM, Cameron RL, Jester DJ, Assefa MT, Staggs H, Adamson MM, Goodman SJ, Snow SJ, Eftim SE, Vincent-Hall TD.   +9 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

'What's in a name? Fit-for-purpose bacterial nomenclature': meeting report. [PDF]

Int J Syst Evol Microbiol
Patrick S, Filkins L, Goker M, Holden N, Hoskisson PA, Kiepas A, Meehan C, Pallen M, Pritchard L, Suchanek AL, Sutcliffe I, Trujillo ME, Tucker N, Turnbull JD, Butler-Wu S.   +14 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

A new, fit-for-purpose regulatory framework for the higher education sector : technical consultation August 2011 [PDF]

, 2011

core  

Are Online Maps and Booking Systems for Antenatal Vaccination Fit for Purpose? A Qualitative Study. [PDF]

Vaccines (Basel)
Tohaia P, Young A, Willing E, Fangupo L, McDonald G.   +4 more
europepmc   +1 more source