Results 221 to 230 of about 82,231,178 (266)

Choosing fit-for-purpose biodiversity impact indicators for agriculture in the Brazilian Cerrado ecoregion. [PDF]

Nat Commun
Rabeschini G, Persson UM, West C, Kastner T.   +3 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Are Current Patient-Reported Outcome Measures Fit for Purpose to Evaluate Unicompartmental Knee Arthroplasty? [PDF]

J Clin Med
Bayram JM, Clement ND, Hall AJ, Walmsley P, Clarke JV.   +4 more
europepmc   +1 more source

Navigating the Real World: A Scoping Review of Structured Frameworks to Effectively Identify, Evaluate, and Select Real-World Data Sources for Fit-for-Purpose Studies. [PDF]

Clin Pharmacol Ther
Zebachi S, Tanniou J, Bakker E, de Vries ST, Di Bidino R, Xoxi E, Glaser A, Savarese G, Hillert J, Mol PGM, Plueschke K, Amzal B, Hayek GY, Moreira J.   +13 more
europepmc   +1 more source

The development process of 'fit-for-purpose' imaging biomarkers to characterize the tumor microenvironment. [PDF]

Front Med (Lausanne)
Eertink JJ, Bahce I, Waterton JC, Huisman MC, Boellaard R, Wunder A, Thiele A, Menke-van der Houven van Oordt CW.   +7 more
europepmc   +1 more source

Evaluating health and social care integration in England's Pioneer programme: The challenges of undertaking research in service delivery and research regulatory systems that are not fit for purpose. [PDF]

J Health Serv Res Policy
Durand MA, Erens B, Wistow G, Hoomans T, Manacorda T, Mays N.   +5 more
europepmc   +1 more source

Effect of fit-for-purpose biochars on rumen fermentation, microbial communities, and methane production in cattle. [PDF]

Front Microbiol
Martinez-Fernandez G, Kinley RD, Smith WJM, Simington J, Joseph S, Tahery S, Durmic Z, Vercoe P.   +7 more
europepmc   +1 more source