Results 81 to 90 of about 2,524,804 (317)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Frontiers in GastroenterologyColonoscopy following a positive FIT test in an average risk population is effective in reducing CRC incidence and mortality. While lower gastrointestinal symptoms remain a common cause for referral for colonoscopy, symptoms are poor predictors of ...
Neil O’Morain +15 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Symposium: Ravishing: The Rose in Fashion: Rose Motifs in the Collection of The Museum at FIT
Colleen Hill and Elizabeth Way present "Rose Motifs in the Collection of The Museum at FIT" for The Museum at FIT's 24th academic symposium Ravishing: The Rose in Fashion on April 30, 2021.
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The neurological manifestations in children with COVID-19 infection
Zdorovʹe RebenkaBackground. Children infected with COVID-19 may experience a variety of neurological symptoms. During the outbreak of COVID-19, doctors should consider SARS-CoV-2 infection as a differential diagnosis when meeting patients with neurological symptoms ...
Ahmed Abdul Hadi Mohsen +4 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FIT Oral History: John Pomerantz (Part 2)
DATE INTERVIEWED: circa 1980sSUMMARY: Mildred Finger interviews John Pomerantz of Leslie Fay, Inc.BIOGRAPHY: "John J. Pomerantz, president of JJP Advisory, LLC, is former chairman and chief executive officer of Leslie Fay Company, Inc., a manufacturer of
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Female Consumer’s Fit Strategies and Fit Perception of Formalwear Rented Online: Content Analysis
, 2013 ITAA Annual Conference ProceedingsWith the advent of Internet technologies, consumers today have extensive opportunities to evaluate products online. Because “consumer reviews, word-of-mouth on the products, could be the most powerful force in the market
McKinney, Ellen C., Shin, Eonyou
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