Results 121 to 130 of about 495,961 (244)

Editorial: Complaints mechanisms in research: are they fit for purpose?

Research Ethics Review, 2022
Kate Chatfield
doaj   +1 more source

State of the industry: integration of 3Rs principles and new approach methodologies in non-clinical product development through fit-for-purpose. [PDF]

Front Med (Lausanne)
Poppenborg SM, Webster DA, Carlsson B.
europepmc   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Are 'evidence-based' cooling strategies fit-for-purpose?-Investigating the gap between guidance and behaviour. [PDF]

BMC Res Notes
Oberai M, Rutherford S, Paas KHW, Bach A, Forbes C, Jackman E, Baker S, Binnewies S, O'Connor FK.   +8 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Reconstructing AF-associated atrial fibrosis: Patient-specific iPSC models, fit-for-purpose atrial microphysiological systems, and nanomedicine. [PDF]

Mater Today Bio
Ni J, Luo Y, Guo R.
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Using co-design to create a fit-for-purpose debriefing framework for at-scale healthcare simulation. [PDF]

Adv Simul (Lond)
Kelly MA, Freer D, Gum L.
europepmc   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

TorpeDNA: a fit-for-purpose eDNA sampling device for marine biodiversity monitoring across applications and scales. [PDF]

PeerJ
Pochon X, Urvois T, Quéméré E, Reynaud Y, Bomati E, Laroche O, Arnaud-Haond S, Trenkel VM, Baulier L, Boussarie G, Saenz-Agudelo P.   +10 more
europepmc   +1 more source