Results 141 to 150 of about 495,961 (244)

Advancing drug development with "Fit-for-Purpose" modeling informed approaches. [PDF]

J Pharmacokinet Pharmacodyn
Sheng J, Zhang T.
europepmc   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

ASO Author Reflections: Physical Functioning in Patients with Sarcoma After Amputation: Are Current Questionnaires Fit for Purpose? [PDF]

Ann Surg Oncol
Bootsma TI, Husson O.
europepmc   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Device-Detected Atrial Fibrillation: Why Time-Based Thresholds Are No Longer Fit for Purpose. [PDF]

J Clin Med
El-Medany A.
europepmc   +1 more source

What can functional transcranial Doppler ultrasonography reveal about the cerebral lateralization of writing

FEBS Letters, EarlyView.
Which brain hemisphere controls writing? This review synthesizes all five functional transcranial Doppler studies of writing (handwriting and typing) published to date in adults and children. Right‐handers show left‐hemispheric dominance for the linguistic component of writing (written word generation), whereas findings for left‐handers remain ...
Marietta Papadatou‐Pastou
wiley   +1 more source

Patient-centred and fit-for-purpose clinical trials in rare cancers: lessons from sarcomas for operationalising 2024 WHO Guidance and ICH E6(R3). [PDF]

EClinicalMedicine
Gonzato O, Reinke D, Wilson R, Kasper B, Ruiz Alvarez MJ.   +4 more
europepmc   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Jet Fuel Effects on Hepatic and Renal Health: A Fit-for-Purpose Systematic Literature Review. [PDF]

J Occup Environ Med
Kotulkar M, Prince LM, Freedman AN, Kolanowski A, Lundin M, Starnes HM, Goodman SJ, Vidal J, Buerk H, Gillera SEA, Tucker NN, Renda RP, Payne LE, Hall SM, Jean-François L, Sprowles JLN, Weinberger KR, Snow SJ, Eftim SE, Haver CE, Bergeron JG, Vincent-Hall TD.   +21 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source