Results 151 to 160 of about 515,021 (268)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Study on the Freeze-Thaw Durability and Carbon Emission Reduction Benefits of Geopolymer EPS Concrete. [PDF]

Materials (Basel)
Jian X, He H, Yuan J, Lei H, Wang S, Shang Y, Shou H, He P, Ding Z, Mao Z.   +9 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Shared spatial and temporal principles govern connectome dynamics across timescales. [PDF]

Proc Natl Acad Sci U S A
Alderson TH, Jun S, Wirsich J, Egan MK, ElSayed SW, Giakas SA, Mostame P, Harper J, Giraud AL, Malone SM, Iacono WG, Koyejo S, Sadaghiani S.   +12 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The effect of orthokeratology lens optical zone size on myopia control in adolescents. [PDF]

Front Med (Lausanne)
Lai L, Long W, Zheng B, Liang Z, He Z, Chen L, Cui D.   +6 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Study on the mechanical characteristics of the stress relaxation in the carbonate rock after high-temperature acidification. [PDF]

Sci Rep
Yang J, Han S, Li L, Peng J, Liu J, Liu J, Han Z.   +6 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Recurrent Copy Number Variants and Psychiatric Outcomes in the Context of Polygenic Scores.

JAMA Psychiatry
Vaez M, Montalbano S, Waples R, Dybdahl Krebs M, Georgii Hellberg KL, Gådin J, Stow D, Holmans P, van den Bree M, Børglum AD, Helenius D, Werge T, Schork AJ, Ingason A, LINC Consortium.   +14 more
europepmc   +1 more source