Results 41 to 50 of about 9,250,019 (280)

Error calibration of five-axis machine tools by on-machine measurement system using a laser displacement sensor

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2014
An on-machine measurement system to measure the workpiece's geometry or dimension plays an important role in manufacturing processes. A laser displacement sensor recently attracts more attention which enables on-machine high-speed continuous ...
Yuu NAGAI, Soichi IBARAKI, Shizuo NISHIKAWA   +2 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

A Review on Real-Time Simulation of CNC Machine Tool Dynamics [PDF]

, 2013
This paper is an endeavour to critically appraise the existing methods used for real-time simulation of machine tool dynamics with the emphasis on modelling and simulation of the dynamic behaviour of CNC machine tool feed drives and mechatronic systems ...
Pislaru, Crinela
core   +2 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Automated planning to minimise uncertainty of machine tool calibration [PDF]

, 2014
When calibrating a machine tool, multiple measurement tasks will be performed, each of which has an associated uncertainty of measurement. International Standards and best-practice guides are available to aid with estimating uncertainty of measurement ...
Longstaff, Andrew P., Parkinson, Simon, S. Parkinson, Fletcher, Simon, S. Fletcher, A.P. Longstaff, Fletcher, S., Longstaff, A. P.; id_orcid, Parkinson, S.   +8 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Geometric Error Analysis and Compensation of Rotary Axes of Five-axis Machine Tools

工程科学与技术, 2020
The position independent geometric errors (PIGEs) of the rotating axes of five-axis machine tools caused by the assembly are the key factor to determine the accuracy of the machine. Quantization analysis of the influence of PIGEs on the accuracy of error
Shijie GUO, Dongsheng ZHANG
doaj  

Machining tests to identify kinematic errors on five-axis machine tools [PDF]

Precision Engineering, 2010
The machining of a cone frustum as specified in National Aerospace Standard (NAS) 979 is widely accepted as a final performance test for five-axis machining centers. Although it gives a good demonstration of the machine’s overall machining performance, it is generally difficult to separately identify each error source in the machine from the measured ...
Ibaraki, Soichi, Sawada, Masahiro, Matsubara, Atsushi, Matsushita, Tetsuya   +3 more
openaire   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source