Results 21 to 30 of about 5,316 (262)

Stiffness-Performance-Based Redundant Motion Planning of a Hybrid Machining Robot

Machines, 2022
Large-scale components usually have complex structures with high local stiffness, and the holes on them are required to be machined with high precision, which makes it important and challenging to study how to efficiently and precisely drill in the large-
Yuhao He, Fugui Xie, Xin-Jun Liu, Zenghui Xie, Huichan Zhao, Yi Yue, Mingwei Li   +6 more
doaj   +1 more source

Tool path generation for sculptured surfaces with 4-axis machining

MATEC Web of Conferences, 2018
Sculpted surfaces are widely used in engineering applications in industries like aerospace, automotive and medical. Commonly, these types of surfaces are manufactured by the process of 5-axis CNC machining. 5-axis machining improves the effectiveness and
Garcia A, Cuan-Urquizo E, Roman-Flores A, Vazquez E   +3 more
doaj   +1 more source

Five-Axis Milling of Large Spiral Bevel Gears: Toolpath Definition, Finishing, and Shape Errors

Metals, 2018
In this paper, a five-axis machining process is analyzed for large spiral-bevel gears, an interesting process for one-of-kind manufacturing. The work is focused on large sized spiral bevel gears manufacturing using universal multitasking machines or five-
Álvaro Álvarez, Amaia Calleja, Naiara Ortega, Luis Norberto López de Lacalle   +3 more
doaj   +1 more source

Influence of spatial position of double turntable swing on dynamic characteristics of five-axis machine tool

Advances in Mechanical Engineering, 2022
In the machining of a five-axis machine tool with a double turntable, the dynamic characteristics of the machine tool are affected by different spatial positions of workpieces.
Shi Wu, Tai Yu, Chunqiang Yuan, Yupeng Wang, Taorui Liu   +4 more
doaj   +1 more source

Rotation-Angle Solution and Singularity Handling of Five-Axis Machine Tools for Dual NURBS Interpolation

Machines, 2023
Dual NURBS interpolation has been proven an essential technique for high-speed precision machining of complex surfaces. The solution of rotation angles and their derivatives is the basis of kinematic transformation and feedrate optimization in dual NURBS
Pengpeng Sun, Qiang Liu, Jian Wang, Zhenshuo Yin, Liuquan Wang   +4 more
doaj   +1 more source

Research on Key Technology of Online Measurement of Five-axis Linkage Machine Tool

Journal of Applied Science and Engineering
In order to improve the machining accuracy and online measurement accuracy of the five-axis linkage machine tool, the motion solution of the double pendulum head five-axis linkage machine tool is realized based on the analysis of the movement and change ...
Dashuang Wang, RongJing Hong
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

High-Efficient Calculation Method for Sensitive PDGEs of Five-Axis Reconfigurable Machine Tool

Machines, 2021
Sensitive geometric errors of a machine tool have significant influence on machining accuracy, and it is important to identify them. Complex modeling and analysis must be carried out to identify the sensitive geometric errors of a five-axis machine tool ...
Zhanqun Song, Shuang Ding, Zhiwei Chen, Zhongwang Lu, Zhouzhou Wang   +4 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source