Results 31 to 40 of about 5,316 (262)

Efficient Prediction of Cutting Force and Stability in Five-Axis Machining of Complex Surfaces Based on Dimensional Compression

Journal of Manufacturing and Materials Processing
With the rapid development of high-end equipment manufacturing, the number and size of complex surfaces continue to increase. Five-axis machining has become the dominant machining method.
Jingyang Feng, Jianning Zhu, Minglong Guo, Xiuru Li, Xueqin Wang   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A Multidimensional Performance Evaluation Method for Blade‑Specialized Five‑Axis Machining Centers

Nanjing Hangkong Hangtian Daxue Xuebao
Machining of aero‑engine blade‑type complex curved‑surface parts places stringent requirements for high accuracy， stability， and efficiency on five‑axis CNC machine tools. To assess the suitability of domestic five‑axis CNC equipment for this application，
LIN Zhiqiang, LU Chengbin, LI Jia, ZHANG Jiacheng, WU Qixun, ZHAO Guolong   +5 more
doaj   +1 more source

Parametric Model Analysis, Geometrical Characteristics and Tool Trajectories to Surface Roughness when Machining the Cycloid Screw by a Five-Axis Milling Machine

Journal of Machine Engineering, 2022
To improve the screw machining accuracy in modern air compressors. This paper investigates three main issues during the development process for cycloid screw machining methods on five-axis CNC machine tools with high precision and efficiency.
Van Bong Pham, Nguyen Van Thien, Van Que Nguyen, Trinh Nguyen Duy, Duy Khanh Nguyen, Dung Hoang Tien   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Research on Multi - axis Machining of Titanium Alloy Integral Impeller [PDF]

MATEC Web of Conferences, 2019
Titanium alloy impeller is hard in material, with large curvature and complex shape, all these factors increase its manufacturing difficulty and machining cost.
Li Guowei
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Study on Non-equant Machining of Globoidal Indexing Cam based on Five-axis NC Machine

Jixie chuandong, 2015
Through the analysis of the meshing principle of globoidal indexing cam,combining with the structure characteristics of the five axis NC machine,the cutter location control equation of the equivalent machining of globoidal indexing cam on five-axis NC ...
Fan Youjun, Bie Yu, Li Yang
doaj  

CUT LAYER IN A MACHINING OF THE CYLINDRICAL GEARS BY THE METHOD OF 5-AXIS ROLL AWAY OF THE END MILL CUTTER ON THE OUTLINE OF THE TOOTH

Technologia i Automatyzacja Montażu, 2021
Gear trains are a key element in the transmission of torque and rotational speed of rotating parts. Technological progress, and five-axis machining in particular, is an interesting and still little-known alternative in the production of this type of ...
Michał Chlost
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source