Results 31 to 40 of about 732,812 (263)

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

A novel geometric error identification methodology for the tilting head of five-axis machine tools based on double ball bar

MATEC Web of Conferences, 2018
The paper proposes a novel geometric error identification methodology for the tilting head of five-axis machine tools using double ball bar(DBB).Firstly, based on the motion condition of the tilting head of five-axis machine tools, three measurement ...
Fan Jinwei, Wu Changjun, Li Zhongsheng
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Space cutter compensation method for five-axis nonuniform rational basis spline machining

Advances in Mechanical Engineering, 2015
In view of the good machining performance of traditional three-axis nonuniform rational basis spline interpolation and the space cutter compensation issue in multi-axis machining, this article presents a triple nonuniform rational basis spline five-axis ...
Yanyu Ding, Taiyong Wang, Bo Li, Jingchuan Dong, Zhe Liu   +4 more
doaj   +1 more source

Development of a comprehensive cardiac atlas on a 1.5 Tesla Magnetic Resonance Linear Accelerator

Physics and Imaging in Radiation Oncology, 2023
Background and purpose: The 1.5 Tesla (T) Magnetic Resonance Linear Accelerator (MRL) provides an innovative modality for improved cardiac imaging when planning radiation treatment.
Aronne M. Schottstaedt, Eric S. Paulson, Jason C. Rubenstein, Xinfeng Chen, Eenas A. Omari, X Allen Li, Chris J. Schultz, Lindsay L. Puckett, Clifford G. Robinson, Filippo Alongi, Elizabeth M. Gore, William A. Hall   +11 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Switching Power Amplifier and Its Improved Current Control Strategy of Active Magnetic Bearing

Kongzhi Yu Xinxi Jishu, 2021
In order to optimize the performance of the magnetic bearing system, a five-axis common-bridge arm topology structure is proposed by analyzing the performance characteristics of magnetic bearing switching power amplifier, which has the advantages of less
HE Xi, HE Yaping, LI Jia
doaj  

Hypothalamic-pituitary-adrenal axis and renin-angiotensin-aldosterone system in adulthood PTSD and childhood maltreatment history

Frontiers in Psychiatry, 2023
Accumulated evidence shows that psychological trauma and posttraumatic stress disorder (PTSD) are associated with dysfunction in the hypothalamic-pituitary-adrenal (HPA) axis.
Ryoko Kakehi, Ryoko Kakehi, Ryoko Kakehi, Hiroaki Hori, Fuyuko Yoshida, Fuyuko Yoshida, Mariko Itoh, Mariko Itoh, Mingming Lin, Madoka Niwa, Megumi Narita, Keiko Ino, Keiko Ino, Risa Imai, Daimei Sasayama, Toshiko Kamo, Hiroshi Kunugi, Hiroshi Kunugi, Yoshiharu Kim   +18 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source