Results 41 to 50 of about 732,812 (263)

Effect of curvature variation on the accuracy of blade NC interpolation

Journal of Advanced Mechanical Design, Systems, and Manufacturing
The curvature variation regularity of the blade surface is complex and requires a high level of machining accuracy. In order to research the influence of interpolation tolerance on the machining accuracy of blade surface at different positions, the non ...
Jiaheng MA, Shengfang ZHANG, Ziguang WANG, Zhihua SHA, Fujian MA   +4 more
doaj   +1 more source

A study on tolerance design of machine tool components based on shape generation motions (Theoretical analysis considering rotational table positions)

Nihon Kikai Gakkai ronbunshu, 2017
The kinematic motion deviations of the five-axis machining centers are deeply influenced by the geometric deviations of the components, such as guide-ways and bearings.
Naoki SATONAKA, Ryo TAKEMATSU, Nobuhiro SUGIMURA, Koji IWAMURA, Yoshitaka TANIMIZU   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A study on tolerance design of machine tool components based on shape generation motions

Nihon Kikai Gakkai ronbunshu, 2016
The kinematic motion deviations of the five-axis machining centers are deeply influenced by the geometric deviations of the components, such as guide-ways and bearings.
Ryo TAKEMATSU, Naoki SATONAKA, Arata YOSHIDA, Nobuhiro SUGIMURA, Koji IWAMURA, Yoshitaka TANIMIZU   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Implementation Method of Five-Axis CNC RTOS Kernel Based on gLink-II Bus

Sensors
With the rapid development of Computerized Numerical Control (CNC) systems, traditional industrial communication protocols fail to meet the requirements for high real-time performance and reliability.
Liangji Chen, Hansong Gao, Huiying Li, Haohao Xu   +3 more
doaj   +1 more source

Improvement of machining accuracy under constant feed speed at milling point with a five axis controlled machining center based on Advanced control Method

Nihon Kikai Gakkai ronbunshu, 2017
Recently, a novel manufacturing technology has spread out with a five-axis machining center, which is controlled by three linear axes and two rotary axes, because the synchronous control technologies make it feasible agilely to create a three-dimensional
Takamaru SUZUKI, Yuma MARUYAMA, Toshiki HIROGAKI, Eiichi AOYAMA   +3 more
doaj   +1 more source

Design of five axis welding robot based on leadshine control system

IOP Conference Series: Materials Science and Engineering, 2019
The five-axis welding robot based on leadshine control system can accomplish various welding tasks in industry, and can accomplish arc welding and linear welding and other welding types. When welding, the machine has small chattering and high welding accuracy. In this paper, the D-H linkage coordinate system and kinematics forward and inverse solutions
Zhao Yongguo, Li Minglei, Wang Peng, Han Yuanda   +3 more
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Study on new thermal error compensation method for complex surface five-axis machining based on new experimental strategy

Advances in Mechanical Engineering
Five-axis machine tools are well-suited for processing complex surface parts. However, during the machining process, thermal error can have a significant impact on the machining accuracy.
Zheng Zou, Qingdong Zhou, Liang He, Zhengyuan Gao, Yong Yang, Jinghua Ma   +5 more
doaj   +1 more source