Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Performance investigations of five-level reduced switches count Η-bridge multilevel inverter
Electrical engineering & Electromechanics, 2023 Introduction. This research paper describes a simple five-level single-phase pulse-width modulated inverter topology for photovoltaic grid applications. Multilevel inverters, as opposed to conventional two-level inverters, include more than two levels of
E. Parimalasundar +3 more
doaj +1 more source
Peak shaving through battery storage for low-voltage enterprises with peak demand pricing [PDF]
, 2020 The renewable energy transition has introduced new electricity tariff structures. With the increased penetration of photovoltaic and wind power systems, users are being charged more for their peak demand.
Desmet, Jan +3 more
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Precise modelling of switching and conduction losses in cascaded h-bridge multilevel inverters [PDF]
, 2014 Nowadays, voltage source multilevel inverters are being used extensively in industry due to its many advantages, compared to conventional two level inverters, such as higher output voltage at low switching frequency, low voltage stress(dv/dt), lower ...
Alamri, B, Darwish, M
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Overview of three-phase inverter topologies for distributed generation purposes [PDF]
, 2010 The increasing presence of single-phase distributed generators and unbalanced loads in the electric power system may lead to unbalance of the three phase voltages, resulting in increased losses and heating.
De Kooning, Jeroen +5 more
core +1 more source
Design and Development of a Class EF2 Inverter and Rectifier for Multi-megahertz Wireless Power Transfer Systems [PDF]
, 2016 This paper presents the design and implementation of a Class EF2 inverter and Class EF2 rectifier for two -W wireless power transfer (WPT) systems, one operating at 6.78 MHz and the other at 27.12 MHz.
Aldhaher, S, Mitcheson, PD, Yates, DC
core +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
A five‐level nested neutral point‐clamped inverter topology
IET Power ElectronicsClassical five‐level nested neutral point‐clamped (5L NNPC) inverter‐leg is a hybrid of the flying‐capacitor and diode‐clamped 5‐L inverter‐leg configurations.
Desmond O. Obe +3 more
doaj +1 more source