Results 131 to 140 of about 1,835,448 (216)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Five-factor model personality traits and cognition in the Harmonized Cognitive Assessment Protocol sub-study of the Survey of Health, Ageing, and Retirement in Europe. [PDF]

Int J Personal Psychol
Luchetti M, Aschwanden D, Karakose S, Stephan Y, Terracciano A, Sutin AR.   +5 more
europepmc   +1 more source

One size does not fit all: Exploring how the five-factor model facets predict disordered eating behaviours among adolescent and young adult males and females. [PDF]

Br J Psychol, 2023
Gilmartin T, Gurvich C, Dipnall JF, Sharp G.   +3 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The Utility of the Five Factor Model of Personality as an Organizing Framework for Autism-Related Traits. [PDF]

Assessment
Widjaja ES, Spackman EK, Bainbridge TF, Ludeke SG, Uljarevic M, Hudry K, Smillie LD.   +6 more
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Relationship Between Personality Traits and Psychological Well-Being in Childhood Obesity: A Cross-Sectional Study Following the Five-Factor Model. [PDF]

Early Interv Psychiatry
Sepúlveda AR, Gil Gómez-Lobo A, Rojo M, Del Blanco-Barredo MDC, Veiga ÓL.   +4 more
europepmc   +1 more source

The Association Between Five Factor Model Personality Traits and Verbal and Numeric Reasoning. [PDF]

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn, 2022
Sutin AR, Stephan Y, Luchetti M, Strickhouser JE, Aschwanden D, Terracciano A.   +5 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Personality as mechanism: An integrative model of five-factor model personality traits as a mechanism between earlier life factors and cognitive aging. [PDF]

Curr Opin Psychol
Sutin AR, Luchetti M, Stephan Y, Terracciano A.   +3 more
europepmc   +1 more source