Results 141 to 150 of about 1,835,448 (216)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Predicting physical activity by the personality styles of the five-factor model. [PDF]

Health Psychol
Weiss A, Costa PT, Collins KA, Ross LM, Huffman KM, Wolever RQ, Smith PJ, Hauser ER, Jiang R, Jakicic JM, Kraus WE, Siegler IC.   +11 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Intimate Partner Violence Perpetration and the Five-Factor Model of Personality: A Systematic Review. [PDF]

Trauma Violence Abuse
Dorling E, Onifade H, Browne K.
europepmc   +1 more source

Distinguishing between trait emotional intelligence and the five-factor model of personality: additive predictive validity of emotional intelligence for negative emotional states. [PDF]

Heliyon, 2022
Sambol S, Suleyman E, Scarfo J, Ball M.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The effect of very preterm birth on the Five-Factor Model of personality traits: A meta-analysis of individual participant data. [PDF]

Eur J Pers
Liu Y, Realo A, Mendonça M, Baumann N, Bartmann P, Räikkönen K, Heinonen K, Robinson R, Marlow N, Johnson S, Ni Y, Kajantie E, Hovi P, Tikanmäki M, Wolke D.   +14 more
europepmc   +1 more source

Corrigendum to: Cortical morphometry of the five-factor model of personality: findings from the Human Connectome Project full sample. [PDF]

Soc Cogn Affect Neurosci, 2021
Owens MM, Hyatt CS, Gray JC, Carter NT, MacKillop J, Miller JD, Sweet LH.   +6 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Five-factor model personality traits, exclusive breastfeeding, and self-efficacy: a mediational analysis. [PDF]

BMC Pregnancy Childbirth
Yadollahi P, Padashian F, Doostfatemeh M.   +2 more
europepmc   +1 more source