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This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Change in Five-Factor Model Personality Traits During the Acute Phase of the Coronavirus Pandemic
Sutin A +7 more
europepmc +1 more source
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Five Concerns with the Five-Factor Model
SSRN Electronic Journal, 2016The new Fama–French five-factor model is likely to become the new benchmark for asset pricing studies. Although the five-factor model exhibits significantly improved explanatory power compared to its predecessor, the classic three-factor model, the authors identify five concerns with regard to the new model.
Blitz, David +3 more
openaire +3 more sources
PERSONALITY STRUCTURE: EMERGENCE OF THE FIVE-FACTOR MODEL
Annual Review of Psychology, 1990J. M. Digman
semanticscholar +3 more sources
The five-factor gambling motivation model
Psychiatry Research, 2007Pathological gambling is a serious social issue, but the underlying psychological motivations are poorly understood. This study developed a five-factor gambling motivation model. The five factors that motivate gambling (socialization, amusement, avoidance, excitement, and monetary motives) were derived from study data obtained from 240 college students.
Heung-Pyo, Lee +3 more
openaire +2 more sources
The five factor model of personality and emotion regulation: A meta-analysis
Personality and Individual Differences, 2019Objective The aim of the present meta-analysis was to examine the relationship between the Big Five personality traits and emotion regulation strategies. Method Studies were identified in PsycArticles, Medline, and Eric databases.
Urszula Barańczuk
semanticscholar +1 more source

