Results 81 to 90 of about 5,888,630 (298)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Big Five Personality Traits, Personal Projects, and Compulsive Buying: A Causal Approach

European Journal of Investigation in Health, Psychology and Education
The purpose of this paper is to predict compulsive buying based on the integration of explanatory units located at different levels of personality analysis (dispositional vs. motivational variables).
José Manuel Otero-López, María José Santiago, María Cristina Castro   +2 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Relações hierárquicas entre os traços amplos do Big Five Hierarchical relationship between the broad traits of the Big Five

Psicologia: Reflexão e Crítica, 2012
O modelo Big Five sustenta que a personalidade humana é composta por dezenas de fatores específicos. Apesar dessa diversidade, esses fatores confluem para cinco traços amplos que estão em um mesmo nível de hierarquia.
Cristiano Mauro Assis Gomes, Hudson Fernandes Golino   +1 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Utility of the bright and dark personality inventory in assessing personality pathology

Frontiers in Psychology
BackgroundContemporary approaches to personality pathology increasingly emphasize dimensional models, a shift reflected in recent diagnostic frameworks such as the DSM-5 Alternative Model for Personality Disorders (AMPD) and the ICD-11. Aligned with this
Eunsil Cho, Eunsil Cho, Yeoul Han, Kee-Hong Choi, Kee-Hong Choi, Kee-Hong Choi   +5 more
doaj   +1 more source

Trichotillomania and personality traits from the five-factor model

Brazilian Journal of Psychiatry, 2015
Objective:To examine whether personality traits have predictive validity for trichotillomania (TTM) diagnosis, pulling severity and control, and hair pulling style.Methods:In study 1, logistic regression was used with TTM cases (n=54) and controls (n=25)
Nancy J. Keuthen, Esther S. Tung, Erin M. Altenburger, Mark A. Blais, David L. Pauls, Christopher A. Flessner   +5 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Personality traits of a successful enterpreneur [PDF]

TIMS: Acta, 2019
A rapid development of the entrepreneurial business in recent years has brought the entrepreneur's personality back into focus. The revival of the old debate regarding the contribution of personal factors to successful business led to the formation of ...
Sokić Jelena, Popov Stanislava
doaj