Results 101 to 110 of about 169,165 (309)

Phase transitions in single neurons and neural populations: Critical slowing, anesthesia, and sleep cycles [PDF]

open access: yes, 2010
The firing of an action potential by a biological neuron represents a dramatic transition from small-scale linear stochastics (subthreshold voltage fluctuations) to gross-scale nonlinear dynamics (birth of a 1-ms voltage spike). In populations of neurons
Sleigh, James W.   +3 more
core   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Harmonic effects on induction and line start permanent magnet machines [PDF]

open access: yes, 2013
Power Electronics (PE) are implemented in a wide variety of appliances, either to increase its controllability or energy efficiency, or simply because a DC supply is needed.
Debruyne, Colin   +2 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Primary electric power generation systems for advanced-technology engines [PDF]

open access: yes, 1983
The advantages of the all electric airplane are discussed. In the all electric airplane the generator is the sole source of electric power; it powers the primary and secondary flight controls, the environmentals, and the landing gear. Five candidates for
Cronin, M. J.
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Evaluation of a multiphase cascaded H-bridge inverter for induction motor operation

open access: yesScientific Reports
Multi-phase systems are becoming more popular for applications requiring high power and precise motor control, even if single-phase AC power is still frequently utilized in households and some enterprises.
B. Jyothi   +7 more
doaj   +1 more source

Reduction of common-mode voltage using a simplified FSC-MPC for a five-phase induction motor drive

open access: yesThe Journal of Engineering, 2019
This paper presents a cascaded closed-loop control of a five-phase induction motor (IM) drive system with common-mode voltage reduction capability. The outer loop uses standard PI regulators for speed reference tracking, while the inner control loop is ...
Hugo Guzman   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Power Quality Enhancement in Electricity Grids with Wind Energy Using Multicell Converters and Energy Storage [PDF]

open access: yes, 2019
In recent years, the wind power industry is experiencing a rapid growth and more wind farms with larger size wind turbines are being connected to the power system.
Allali, Ahmed   +5 more
core   +2 more sources

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