Results 21 to 30 of about 22,958 (200)

Comparative Analysis of V-Akt Murine Thymoma Viral Oncogene Homolog 3 (AKT3) Gene between Cow and Buffalo Reveals Substantial Differences for Mastitis [PDF]

, 2018
AKT3 gene is a constituent of the serine/threonine protein kinase family and plays a crucial role in synthesis of milk fats and cholesterol by regulating activity of the sterol regulatory element binding protein (SREBP).
Ahmad, H I, Ahmad, M J, Bhattarai, D, Brohi, R D, Cheng, Z R, Deng, T, Khan, M, Liang, X, Rehman, Z U, Safdar, M, Salim, M, Talpur, H S, Ullah, F, Worku, T, Zhang, S   +14 more
core   +2 more sources

Positive epistasis between viral polymerase and the 3′ untranslated region of its genome reveals the epidemiologic fitness of dengue virus

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Dengue affects approximately one-half of the world’s population. While it causes regular and cyclical outbreaks throughout the tropical world, the molecular mechanisms that determine its epidemic potential remain poorly defined.
A. Syenina, D. Vijaykrishna, E. Gan, H. Tan, M. Choy, Tanamas Siriphanitchakorn, C. Cheng, S. Vasudevan, E. Ooi   +8 more
semanticscholar   +1 more source

Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities [PDF]

, 2017
Dengue virus (DENV) is the leading mosquito-transmitted viral infection in the world. With more than 390 million new infections annually, and up to 1 million clinical cases with severe disease manifestations, there continues to be a need to develop new ...
Coluccia, A., Famiglini, V., Hiscott, J., La Regina, G., Lee, J. C., Masci, D., Pelliccia, S., Silvestri, R., Tseng, C. K., Wub, Y. H.   +9 more
core   +1 more source

Formation, regulation and evolution of Caenorhabditis elegans 3'UTRs [PDF]

, 2010
Post-transcriptional gene regulation frequently occurs through elements in mRNA 3′ untranslated regions (UTRs)1, 2. Although crucial roles for 3′UTR-mediated gene regulation have been found in Caenorhabditis elegans3, 4, 5, most C.
Bartel, David, Friedman, Robin Carl, Jan, Calvin H., Ruby, J. Graham   +3 more
core   +2 more sources

Characterization of Ovine A3Z1 Restriction Properties against Small Ruminant Lentiviruses (SRLVs) [PDF]

, 2017
Intrinsic factors of the innate immune system include the apolipoprotein B editing enzyme catalytic polypeptide-like 3 (APOBEC3) protein family. APOBEC3 inhibits replication of different virus families by cytosine deamination of viral DNA and a not fully
Amorena, Beatriz, Andrésdóttir, Valgerður, Crespo, Helena, de Andrés, Damián, de Pablo-Maiso, Lorena, Glaria, Idoia, Nistal-Villán, Estanislao, Reina, Ramsés   +7 more
core   +2 more sources

Characteristics of the Iron-responsive Element (IRE) Stems in the Untranslated Regions of Animal mRNAs

, 2021
Background: Iron-responsive Elements (IREs) are hairpin structures located in the 5’ or 3’ untranslated region of some animal mRNAs. IREs have a highly conserved terminal loop and a UGC/C or C bulge five bases upstream of the terminal loop, which divides
Bin Wang, Michael S. Thompson, Kevin M. Adkins   +2 more
semanticscholar   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

NOTCH2NLC Repeat Expansions in Parkinsonian Disorders: Clinical and Neuroimaging Characteristics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disorder caused by NOTCH2NLC GGC repeat expansions, with heterogeneous clinical manifestations, including parkinsonism. Recent studies have identified NOTCH2NLC repeat expansions in patients with Parkinson's disease (PD) and atypical parkinsonism (aPM), suggesting ...
Han‐Lin Chiang, Kang‐Yang Jih, Cheng‐Tsung Hsiao, Fu‐Pang Chang, Justus Chunyu Chen, Yi‐Chu Liao, Yih‐Ru Wu, Yi‐Chung Lee   +7 more
wiley   +1 more source

Magnetic Resonance Imaging‐Based Quantification of Endosomal Escape Using Iron Oxide Nanoparticle‐Loaded Lipid Nanoparticles

Advanced Healthcare Materials, EarlyView.
The therapeutic efficacy of lipid nanoparticle(LNP)‐based drugs depends on endosomal escape. However, few methods are available for quantifying the efficiency of endosomal escape in vivo. Herein, a novel method for quantifying the endosomal escape efficiency index using magnetic resonance imaging is introduced.
Somin Lee, Jeongbin Park, Han Na Jung, Shengjun Li, Zhijun Lin, Hyung‐Jun Im   +5 more
wiley   +1 more source

Metal inducible activity of the oil palm metallothionein-like gene promoter (MT3-A) in prokaryotes. [PDF]

, 2011
Reporter gene activity under the regulation of the oil palm metallothionein-like gene, MT3-A promoter was assessed in prokaryotes. Vector constructs containing MT3-A promoter with (W1MT3-A) and without (W2MT3-A) five prime untranslated region (5'-UTR ...
Abdul Aziz, Maheran, Abdullah, Siti Nor Akmar, Kamaladini, Hossein   +2 more
core   +1 more source