Results 51 to 60 of about 22,958 (200)

Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response. [PDF]

, 1992
Although much has been learned about the molecular basis of immunoglobulin M (IgM) rheumatoid factors (RFs) in healthy individuals and in patients with mixed cryoglobulinemia and rheumatoid arthritis, little is known about the genetic origins of the ...
Carson, DA, Chen, PP, Deftos, M, Huang, DF, Kozin, F, Lu, EW, Olee, T, Soto-Gil, RW   +7 more
core  

Sequence and Structural Analysis of 3' Untranslated Region of Hepatitis C Virus, Genotype 3a, From Pakistani Isolates

Hepatitis Monthly, 2013
Background Hepatitis C virus (HCV) is the cause of high morbidity and mortality worldwide, inflicting around one million people in Pakistan alone. The HCV genomic RNA harbors conserved structural elements that are indispensable for its replication. The 3’
Sadia Anjum, Sidra Ali, Tahir Ahmad, M. Afzal, Yasir Waheed, Talha Shafi, Muhammad Ashraf, S. Andleeb   +7 more
semanticscholar   +1 more source

LncRNA TMEM99 Complexes with IGF2BP2 to Inhibit Autophagy in Lung Adenocarcinoma

Advanced Science, EarlyView.
LncRNA TMEM99 is significantly upregulated in lung adenocarcinoma (LUAD) and correlates with poor prognosis. It promotes LUAD cell proliferation, migration, and invasion while suppressing autophagy. Mechanistically, TMEM99 binds FUBP3 and recruits IGF2BP2 in an m⁶A‐dependent manner to stabilize and enhance p21 mRNA translation, uncovering a novel ...
Zhigang Wu, Yue Zhao, Yizhou Peng, Pengcheng Liu, Qixuan Huang, Yang Wo, Yunjian Pan, DongDong Zheng, Chongze Yuan, Yan Shang, Xiao Chen, Hui Hong, Yihua Sun   +12 more
wiley   +1 more source

Regulation of expression of the rat orthologue of mouse double minute 2 (MDM2) by H2O2-induced oxidative stress in neonatal rat cardiac myocytes. [PDF]

, 2009
The Mdm2 ubiquitin ligase is an important regulator of p53 abundance and p53-dependent apoptosis. Mdm2 expression is frequently regulated by a p53 Mdm2 autoregulatory loop whereby p53 stimulates Mdm2 expression and hence its own degradation.
Andrew K. Marshall, Andrews, Angel, Angela Clerk, Balvinder S. Handa, Barak, Bogoyevitch, Bonini, Bradford, Brown, Cahilly-Snyder, Clerk, Clerk, Clerk, Clerk, Cook, Cullingford, Dey, El Li Tham, el-Deiry, Fakharzadeh, Fang, Foo, Grier, Halees, Harrison, Hollenhorst, Honda, Hromas, Iwaki, Jin, Karin, Kawamura, Kemp, Kenneth Lay, Leri, Leri, Long, McNeill-Blue, Mendrysa, Morris, Murphy, Peirce, Peter H. Sugden, Phelps, Poizat, Ries, Robert A. Kennedy, Sampsa Pikkarainen, Saucedo, Sharrocks, Shaulian, Siwik, Solaini, Sugden, Suzuki, Thomas A. Kriz, Toledo, Tortora, Toth, Truong, Uberti, Vanden Hoek, Veprintsev, von Harsdorf, Yoneda   +65 more
core   +2 more sources

Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities

Advanced Science, EarlyView.
Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Irafasha C. Casmil, Josh J. Friesen, Nuthan V. Bathula, Anneke Strumpel, Chia Hao Ho, Ilana Guez, Kristen Y. S. Kong, Andrew J. Varley, Shigeki J. Miyake‐Stoner, Parinaz Aliahmad, Nathaniel S. Wang, Andrew J. Geall, Anna K. Blakney   +12 more
wiley   +1 more source

Dynamic eIF3‐S6 Phase Separation Switch Instructed by m6A Modification Drives the Molting of Locusts

Advanced Science, EarlyView.
This research reveals that reduced m6A modifications during insect molting trigger liquid–liquid phase separation (LLPS) of the m6A reader eIF3‐S6, which binds and stabilizes key molting mRNAs, including EcR and Cht10. Disrupting m6A or LLPS causes cuticle remodeling defects and molting failure, highlighting the synergistic control of gene expression ...
Zhihao Hu, Yu Zhou, Huimin Wang, Yaxi Wu, Rui Han, Shili Liu, Feng Jiang, Xiaojiao Guo, Meiling Yang   +8 more
wiley   +1 more source

Licensed human natural killer cells aid dendritic cell maturation via TNFSF14/LIGHT [PDF]

, 2014
Interactions between natural killer (NK) cells and dendritic cells (DC) aid DC maturation and promote T cell responses. Here, we have analysed the response of human NK cells to tumor cells and we identify a pathway by which NK-DC interactions occur ...
Andrew V. Benest, Betty Tan, Candida Vaz, Emma V. I. Black, Erica B. Wilson, Frey, Graham P. Cook, Tim D. Holmes, Vivek M. Tanavde   +8 more
core   +2 more sources

Transplanting neural stem cells overexpressing miRNA‐21 can promote neural recovery after cerebral hemorrhage through the SOX2/LIN28‐let‐7 signaling pathway

Animal Models and Experimental Medicine, EarlyView.
Abstract Background Intracerebral hemorrhage (ICH) remains a devastating neurological disorder with limited therapeutic options. Neural stem cell (NSC)‐based therapies have emerged as a potential regenerative approach, yet the molecular mechanisms regulating NSC behavior require further elucidation.
Wei Dai, Yongxia Li, Jiarui Du, Gang Shen, Meimei Fan, Zuopeng Su, Fulin Xu, Fang Yuan   +7 more
wiley   +1 more source

Infrared Fluorescent Imaging as a Potent Tool for In Vitro, Ex Vivo and In Vivo Models of Visceral Leishmaniasis [PDF]

, 2015
Visceral leishmaniasis (VL) is hypoendemic in the Mediterranean region, where it is caused by the protozoan Leishmania infantum. An effective vaccine for humans is not yet available and the severe side-effects of the drugs in clinical use, linked to the ...
Balaña-Fouce, R., Calvo-Álvarez, E., Escudero-Martínez, J. M., Fresno, M., Punzón, C., Pérez-Pertejo, Y., Reguera, R. M., Stamatakis, Konstantinos, Tejería, A., Álvarez-Velilla, R.   +9 more
core   +4 more sources

Identification of Cis-Acting Elements in the 3′-Untranslated Region of the Dengue Virus Type 2 RNA That Modulate Translation and Replication*

Journal of Biological Chemistry, 2011
Using the massively parallel genetic algorithm for RNA folding, we show that the core region of the 3′-untranslated region of the dengue virus (DENV) RNA can form two dumbbell structures (5′- and 3′-DBs) of unequal frequencies of occurrence.
Mark Manzano, E. Reichert, S. Polo, B. Falgout, W. Kasprzak, B. Shapiro, R. Padmanabhan   +6 more
semanticscholar   +1 more source