Results 141 to 150 of about 317,820 (317)

Comprehensive analyses for genetic diversities of 19 autosomal STRs in Chinese Kazak group and its phylogenetic relationships with other continental populations

Forensic Sciences Research, 2020
Short tandem repeats (STRs) play an essential role in forensic genetics due to their high degree of polymorphisms, wide distributions and easy detection method.
Yijie Wang, Xiaoye Jin, Wenqing Zhang, Wei Cui, Tingting Kong, Chong Chen, Yuxin Guo, Haotian Meng, Bofeng Zhu   +8 more
doaj   +1 more source

Rate of Adaptation in Large Sexual Populations

, 2010
Adaptation often involves the acquisition of a large number of genomic changes which arise as mutations in single individuals. In asexual populations, combinations of mutations can fix only when they arise in the same lineage, but for populations in ...
Fisher, Daniel S., Neher, Richard A., Shraiman, Boris I.   +2 more
core   +2 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Genetic Drift and Mutation [PDF]

arXiv, 2018
In genetic drift of small population, it is well known that even when the ratio of alleles is 0.5, specific genes are fixed in or disappear from the population. It seems the reason why inbreeding is avoided. On the other hand, this phenomenon suggests an interesting possibility.
arxiv  

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Anthropogenic and natural fragmentations shape the spatial distribution and genetic diversity of roe deer in the marginal area of its geographic range

Ecological Indicators, 2023
Habitat destruction and fragmentation are major factors in the destruction of genetic diversity and affect the movement behavior of the Roe deer population in the remaining habitats.
Shirin Mahmoodi, Kourosh Ahmadi, Afshin Alizadeh Shabani, Mehrshad Zeinalabedini, Arash Javanmard, Olyagholi Khalilipour, Mohammad Hossein Banabazi   +6 more
doaj  

Genetic diversity of toll-like receptor genes in the vulnerable Chinese egret (Egretta eulophotes).

PLoS ONE, 2020
Toll-like receptor (TLR) genes have recently been employed to assess genetic diversity, as they can be used to infer both demographic history and adaptation to environments with different pathogen pressure. Here, we sampled 120 individuals of the Chinese
Wei Xu, Xiaoping Zhou, Wenzhen Fang, Xiaolin Chen   +3 more
doaj   +1 more source

The Dynamics of Genetic Draft in Rapidly Adapting Populations [PDF]

arXiv, 2013
The accumulation of beneficial mutations on many competing genetic backgrounds in rapidly adapting populations has a striking impact on evolutionary dynamics. This effect, known as clonal interference, causes erratic fluctuations in the frequencies of observed mutations, randomizes the fixation times of successful mutations, and leaves distinct ...
arxiv  

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

The effect of recurrent mutations on genetic diversity in a large population of varying size [PDF]

arXiv, 2015
Recurrent mutations are a common phenomenon in population genetics. They may be at the origin of the fixation of a new genotype, if they give a phenotypic advantage to the carriers of the new mutation. In this paper, we are interested in the genetic signature left by a selective sweep induced by recurrent mutations at a given locus from an allele A to ...
arxiv