Results 151 to 160 of about 317,820 (317)

Stochastic slowdown in evolutionary processes

, 2010
We examine birth--death processes with state dependent transition probabilities and at least one absorbing boundary. In evolution, this describes selection acting on two different types in a finite population where reproductive events occur successively.
Arne Traulsen, C. W. Gardiner, Chaitanya S. Gokhale, M. Nei, N. G. v. Kampen, N. Goel, P. A. P. Moran, P. Schuster, Philipp M. Altrock, R. Bürger, S. Karlin, S. Redner, T. Maruyama, W. Feller, W. J. Ewens   +14 more
core   +1 more source

The impact of habitat fragmentation and social structure on the population genetics of roe deer (Capreolus capreolus L.) in Central Europe

Heredity, 2001
Nine out of 57 bovine and caprine microsatellites investigated have proved polymorphic in roe deer populations from Central Europe. The polymorphism of four to nine microsatellites (with two to 16 alleles each) has been screened in 492 roe deer from 27 ...
Ma-Li Wang, A. Schreiber
semanticscholar   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Low genetic diversity and intrapopulation spatial genetic structure of the Atlantic Forest tree, Esenbeckia leiocarpa Engl. (Rutaceae)

Annals of Forest Research, 2014
Studies on population genetics are the key to designing effective in situ management plans for tree species, in particular, those subjected to pressure from anthropogenic processes, such as forest fragmentation and logging.
G. Forti, E.V. Tambarussi, P.Y. Kageyama, M.A. Moreno, E.M. Ferraz, B. Ibañes, R. Vencovsky, G.M. Mori, A.M. Sebbenn   +8 more
doaj   +1 more source

Stochastic modeling of density-dependent diploid populations and extinction vortex [PDF]

arXiv, 2012
We model and study the genetic evolution and conservation of a population of diploid hermaphroditic organisms, evolving continuously in time and subject to resource competition. In the absence of mutations, the population follows a 3-type nonlinear birth-and-death process, in which birth rates are designed to integrate Mendelian reproduction.
arxiv  

Germline variants in CDKN2A wild‐type melanoma prone families

Molecular Oncology, EarlyView.
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen, Marie Loeng, Amalie Lund Holth, Per E. Lønning, Jürgen Geisler, Stian Knappskog   +5 more
wiley   +1 more source

Fixation and absorption in a fluctuating environment [PDF]

arXiv, 2017
A fundamental problem in the fields of population genetics, evolution, and community ecology, is the fate of a single mutant, or invader, introduced in a finite population of wild types. For a fixed-size community of $N$ individuals, with Markovian, zero-sum dynamics driven by stochastic birth-death events, the mutant population eventually reaches ...
arxiv  

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Inference of Selection from Genetic Time Series Using Various Parametric Approximations to the Wright-Fisher Model

G3: Genes, Genomes, Genetics, 2019
Detecting genomic regions under selection is an important objective of population genetics. Typical analyses for this goal are based on exploiting genetic diversity patterns in present time data but rapid advances in DNA sequencing have increased the ...
Cyriel Paris, Bertrand Servin, Simon Boitard   +2 more
doaj   +1 more source

Population genetics of Zostera noltii along the west Iberian coast: consequences of small population size, habitat discontinuity and near-shore currents

, 2005
The effects of oceanographic patterns on marine genetic biodiversity along the SW Iberian Peninsula are poorly understood. We addressed the question of whether gene flow in this region depends solely on geographic distance between isolated patches of ...
O. Diekmann, J. Coyer, J. Ferreira, J. Olsen, W. Stam, G. Pearson, E. Serrão   +6 more
semanticscholar   +1 more source