Results 151 to 160 of about 158,082 (381)

β‐Mangostin Attenuates TET2‐Mediated DNA Demethylation of Prkcg in the Prevention of Intervertebral Disc Degeneration

Advanced Science, EarlyView.
β‐Mangostin alleviates intervertebral disc degeneration through dual modulation of macrophage polarization and the TET2‐Prkcg axis in nucleus pulposus cells. Abstract Intervertebral disc degeneration (IDD) induced lower back pain is a main cause of disability, resulting in a substantial workforce loss worldwide and placing a substantial burden on the ...
Xiangzhen Kong, Hanwen Gu, Yuanqiang Zhang, Qunbo Meng, Qi Li, Kangle Song, Yanlin Li, Kaiwen Liu, Zhenchuan Liu, Rui Hu, Haoxi Zhai, Tian Li, Zemin Ling, Zhijian Wei, Fuxin Wei, Lei Cheng   +15 more
wiley   +1 more source

The effect of reusing formaldehyde fixative solution on the quality of histopathological slides and the amount of waste produced

Current Biomedicine
Background: Neutral buffered formalin (NBF) 10% fixative solution is widely used in histopathological slides. The fixation process generates liquid waste of NBF 10% and solid waste of tissue remnants. Objective: The research aimed to assess the reuse of
Zon Hardi, Wiwin Wiryanti, Adang Durachim, Mamat Rahmat   +3 more
doaj   +1 more source

Fixing the internet [PDF]

Science, 2018
Data breaches at Facebook and Google—and along with Amazon, those firms' online dominance—crest a growing wave of anxiety around the internet's evolving structure and its impact on humanity. Three keys to the decades-long global expansion of the internet and the World Wide Web are breaking down.
openaire   +4 more sources

The Long Noncoding RNA ΒFaar Promotes White Adipose Tissue Browning and Prevents Diet‐Induced Obesity

Advanced Science, EarlyView.
βFaar selectively targets and inhibits the GTPase activity of the RAB18 protein, thereby reducing LD volume. Conversely, βFaar promotes nuclear translocation of the transcription factor IRF4 in inguinal white adipose tissue (iWAT), facilitating the browning of white adipose tissue and attenuating body fat accumulation.
Yue Yang, Bin Huang, Baixue Sha, Danni Gao, Yimeng Qin, Ziyi Li, Xi Chen, Yinuo Jin, Yi Pan, Yanfeng Zhang, Yumeng Shen, Yu Liu, Liang Jin, Fangfang Zhang   +13 more
wiley   +1 more source

UTX Responds to Nanotopography to Suppress Macrophage Inflammatory Response by Remodeling H3K27me3 Modification

Advanced Science, EarlyView.
Compared with those on the pTi surface, macrophages on the TNTs surface present reduced myosin II contractility, which facilitates the nuclear translocation of the UTX. This reduction decreases the enrichment of the repressive H3K27me3 histone modification at the Abca1 gene locus, which promotes the transcription and protein expression of ABCA1 ...
Hengji Jia, He Zhang, Dingqiang Mo, Bo Xie, Hongdou Qiao, Tao Chen, Haoyue Song, Xinxin Xu, Sheng Yang   +8 more
wiley   +1 more source

Adição de NaCI em soluções fixadoras - observações histológicas e histoquímicas
Addition of NaCl in fixative solutions - histological and histochemical observations

Semina: Ciências Sociais e Humanas, 1981
Análise comparativa entre os resultados obtidos após fixação com formol neutro a 10% e com Bouin (convencional) e os resultados obtidos após fixação com essas mesmas soluções acrescidas de NaCI na concentração de 0,7% O orgão-objeto de análise foi a ...
Ivan Giacomo Piza, Arestides Massao Nachi   +1 more
doaj  

Advances in methods for determining fecundity: application of the new methods to some marine fishes [PDF]

, 2009
Estimation of individual egg production (realized fecundity) is a key step either to understand the stock and recruit relationship or to carry out fisheries-independent assessment of spawning stock biomass using egg production methods.
Dominguez, Rosario, Greenwood, Lorraine N., Kjesbu, Olav S., Korta, Maria, Murua, Hilario, Saborido-Rey, Francisco, Thorsen, Anders, Witthames, Peter R.   +7 more
core  

Modulating Macrophage–Nucleus Pulposus Cell Crosstalk via Sequential Drug Delivery Attenuates Disc Degeneration

Advanced Science, EarlyView.
The G‐CS/MSN drug delivery system enhances intervertebral disc repair through sequential drug release. Abstract Intervertebral disc degeneration (IDD) is characterized by an inflammatory environment and dysregulation of the extracellular matrix metabolism (ECM).
Xiangzhen Kong, Rui Hu, Peng Zhang, Qi Li, Kangle Song, Hanwen Gu, Jihui Zheng, Shen Liu, Liang Liu, Lin Jin, Lei Cheng, Chengwei Li, Zhijian Wei   +12 more
wiley   +1 more source

The Effect of Primary Fixation with Standard Postfixation and the Duration of Hydrolysis on Nuclear Features in Image Cytometry

Analytical Cellular Pathology, 1998
The effect of three primary fixation procedures, used in the preparation of routine cytological samples: air-drying, Delaunay, and Saccomanno fixation, with postfixation in modified Böhm–Sprenger fixative, on nuclear features as a function of hydrolysis ...
Margareta Fležar, Alexei Doudkine, Marija Us-Krašovec   +2 more
doaj   +1 more source

The fixative action of uranyl acetate in electron microscopy [PDF]

, 1968
M. T. Silva, Francisco Guerra, M. M. Magalhães   +2 more
openalex   +1 more source