Results 151 to 160 of about 146,660 (246)

Melatonin Exerts Chondroprotective Effects Against Osteoarthritis by Promoting PI3K/AKT/FoxO3‐Mediated Mitophagy

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a prevalent degenerative joint disease. This study combines bioinformatics analysis with in vivo and in vitro experiments to elucidate the molecular mechanisms through which melatonin (MT) regulates mitophagy to alleviate OA.
Chao Huang, Gang Zhang, Ying‐Kai Ma, Xin‐Nan Ma, Song‐Cen Lv   +4 more
wiley   +1 more source

In Situ Analysis of Historical Preservation Fluids in Sealed Containers with Spatially Offset Raman Spectroscopy. [PDF]

ACS Omega
Blanco A, Montgomery W, Walker S, McKibbin C, Stokes R, Matousek P, Mosca S.   +6 more
europepmc   +1 more source

PRDM1 Knockdown Promotes Ferroptosis and Sunitinib Sensitivity by Modulating the PI3K/Akt Signaling Through Inhibition of ESM1 Transcription in Renal Cell Carcinoma

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Renal cell carcinoma (RCC) is a commonly occurring and considerable burden on public health. Although chemotherapy benefits patients with advanced RCC, sunitinib resistance leads to a poor prognosis. Ferroptosis is also involved in sunitinib resistance in RCC.
Yi‐Shuai Zhang, Xin‐Qi Pei, Ji‐Ping Sun, Chen‐Hui Ma, Xin‐Yang Wang, Xu‐Dong Li   +5 more
wiley   +1 more source

Long-term fixation impact on archived human nervous tissues for sequencing-based transcriptomics. [PDF]

Brain Commun
Howe S, McCann H, Xiong Z, Nguyen Q, Steyn FJ, Ngo ST, Chang J.   +6 more
europepmc   +1 more source

Dynamic Profiling of Circulating Tumor Cells and MYC/PTEN Alterations in Prostate Cancer Patients Undergoing Radical Prostatectomy in Amazon Population

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed malignancy among men and the sixth leading cause of cancer‐related mortality worldwide. Radical prostatectomy remains the standard treatment for localized disease; however, approximately one‐third of patients develop biochemical recurrence within 10 years. Although prostate‐specific
Juliana Ramos Chaves, Rommel Mario Rodriguez Burbano, Amanda de Nazaré Cohen‐Paes, Diego Di Felipe Ávila Alcântara, Ana Paula Borges de Souza, Maria Janete Nahum Gomes, Sérgio Augusto Antunes Ramos, André Salim Khayat   +7 more
wiley   +1 more source

A Method of Well-Spread Pachytene Chromosome Preparations for Plant Species with Large Genomes Suitable for the Immunolocalization of Meiotic Proteins. [PDF]

Methods Protoc
Kudryavtseva N, Ermolaev A, Khrustaleva L.   +2 more
europepmc   +1 more source

Quantitative Comparison of Multi‐Echo Spin Echo and Multi‐Echo Gradient Echo Myelin Water Imaging in a Panel of Mbp Enhancer‐Edited Mouse Lines

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To evaluate the correspondence between myelin water fraction (MWF) estimates derived from multi‐echo spin echo (MESE) and multi‐echo gradient echo (MGRE) imaging in fixed mouse brain tissue, using a panel of myelin basic protein (Mbp) enhancer‐edited mouse lines exhibiting graded hypomyelination.
Vladimir Grouza, Yawen Shi, Sean Goldfarb, Klaudia M. Bednarz, Isabella Gomez, Marius Tuznik, Zhe Wu, Hooman Bagheri, Katherine A. Siminovitch, Alan C. Peterson, Thomas Stroh, David A. Rudko   +11 more
wiley   +1 more source

Assessing the sequencing success and analytical specificity of a targeted amplicon deep sequencing workflow for genotyping the foodborne parasite <i>Cyclospora</i>. [PDF]

J Clin Microbiol
Peterson AC, Jacobson D, Richins T, Barratt J, Qvarnstrom Y.   +4 more
europepmc   +1 more source

Juvenile hormone‐mediated accelerated post‐flight recovery of ovarian development in Loxostege sticticalis (Lepidoptera: Crambidae)

New Plant Protection, EarlyView.
Flight in female beet webworms (Loxostege sticticalis) promotes an increase in feeding, thereby enhancing abdominal energy reserves. Following flight, the flight muscles undergo accelerated histolysis, and the energy substances undergoing histolysis are redirected to the ovaries. These two processes collectively promote ovarian development.
Yu Gao, Yunxia Cheng, Wenyi Song, Lei Zhang, Dianjie Xie, Xingfu Jiang   +5 more
wiley   +1 more source

Evaluation of Glyoxal fixation for immunohistochemistry of the retina. [PDF]

Sci Rep
Chidlow G, Wood JPM, Chan WO, Casson RJ.
europepmc   +1 more source