Results 151 to 160 of about 4,911,014 (257)

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Effectiveness and Safety of Fixed-Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real-World Study From China. [PDF]

J Diabetes
Ke W, Kong Y, Fu S, Wang L, Pan Y, Zhong S, Jiang Y, Chen H, Jiao X, Sha F, Xu L, Shao W, Lan F, Chen X, Yan B, Zhou G, Shi P, Li F, He H, Li H, Zhang G, Duan H, Wang F, Gong W, Bai Y, Wang B, Mou X, He L, Ma W, Song J, Zheng J, Bai X, Li X, Yan X, Wang Y, Wang Z, Yuan J, Lu W, Liang Y, Wang Y, Xu F, Li X, Lin X, Zhu H, Xu L, Lou X, Wang L, Cui L, Wang L, Qian H, Shi Y, Li Y.   +51 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Effectiveness and tolerability of cephalexin and clavulanic acid fixed dose combination, amoxicillin and clavulanic acid fixed dose combination, and azithromycin in patients with pharyngitis in India: a real-world retrospective study from electronic medical records (PHARYSPOR). [PDF]

Front Med (Lausanne)
Sarof S, Somana NK, S RC, Venkataram RC, R JS, Sv S, Peddi R, K S, Vohra NR, Bhama LK, Shah M, Chile V, Gunderia A, Momin F, Banerjee A, Kumar S, Rungta S, Ikbal A, Singhvi S, Natarajan A, Mitra M, Kadam V, Dharmadhikari S, Khandhedia C, Puppalwar G, Markandeywar N, Mane A, Mehta S.   +27 more
europepmc   +1 more source

Role of triple fixed combination valsartan, amlodipine and hydrochlorothiazide in controlling blood pressure

, 2010
Monica Doménech, Antonio CocaHypertension Unit, Department of Internal Medicine, Institute of Internal Medicine and Dermatology, Hospital Clinic (IDIBAPS), University of Barcelona, SpainAbstract: Hypertension is one of the main risk factors ...
Antonio Coca, Monica Doménech
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Simulation-Based Predictions to Support the Development of a Pediatric Fixed-Dose Combination of Dolutegravir/Emtricitabine/Tenofovir Alafenamide Fumarate. [PDF]

Clin Pharmacokinet
Waalewijn H, Bevers LAH, Lewis LL, Louey MD, Kawakatsu S, Zheng Y, Giaquinto C, Nardone A, Burger DM, Ter Heine R, Colbers A, Svensson EM.   +11 more
europepmc   +1 more source

Fixperts films archive

, 2017
The Fixperts film archive hosts the documentation aspect of design based Fixperts projects from participants all around the world. It is managed though Youtube and disseminated through a dedicated online platform on the FixEd website.
Charny, Daniel, FixEd
core  

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Efficacy of ripasudil-brimonidine fixed-dose combination in secondary glaucoma associated with uveitis: a retrospective study. [PDF]

Jpn J Ophthalmol
Miyao K, Imazeki M, Oyama T, Nakai S, Kanda T, Takeuchi M.   +5 more
europepmc   +1 more source