Results 91 to 100 of about 42,360 (298)

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Removing $$\delta $$ δ -dependence in minimal interpretable model learning: distribution conditions and structural parameters

Journal of King Saud University: Computer and Information Sciences
Learning minimal interpretable models (e.g., decision trees, decision sets, and binary decision diagrams) is computationally challenging, yet increasingly important in high-stakes settings.
Zhigao Huang, Shiyan Zheng, Quanfa Li
doaj   +1 more source

AutomataGPT: Transformer‐Based Forecasting and Ruleset Inference for Two‐Dimensional Cellular Automata

Advanced Science, EarlyView.
We introduce AutomataGPT, a generative pretrained transformer (GPT) trained on synthetic spatiotemporal data from 2D cellular automata to learn symbolic rules. Demonstrating strong performance on both forward and inverse tasks, AutomataGPT establishes a scalable, domain‐agnostic framework for interpretable modeling, paving the way for future ...
Jaime A. Berkovich, Noah S. David, Markus J. Buehler   +2 more
wiley   +1 more source

Fixed-parameter tractability of Directed Multicut with three terminal pairs parameterized by the size of the cutset: twin-width meets flow-augmentation [PDF]

, 2022
Meike Hatzel, Lars Jaffke, Paloma T. Lima, Tomáš Masařík, Marcin Pilipczuk, Roohani Sharma, Manuel Sorge   +6 more
openalex   +1 more source

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Energy Distribution Optimization in Heterogeneous Networks with Min–Max and Local Constraints as Support of Ambient Intelligence

Sensors
In recent years, ambient intelligence (AmI) has gained significant attention from both academia and industry. AmI seeks to create environments that automatically adapt to individuals’ needs, improving comfort and efficiency.
Alessandro Aloisio, Domenico D. Bloisi, Marco Romano, Cosimo Vinci   +3 more
doaj   +1 more source

Chordless Cycle Packing Is Fixed-Parameter Tractable

28th Annual European Symposium on Algorithms (ESA 2020), 2020
A chordless cycle or hole in a graph G is an induced cycle of length at least 4. In the Hole Packing problem, a graph G and an integer k is given, and the task is to find (if exists) a set of k pairwise vertex-disjoint chordless cycles. Our main result is showing that Hole Packing is fixed-parameter tractable (FPT), that is, can be solved in time f(k)n^
openaire   +3 more sources

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

Parameterized Complexity Results for General Factors in Bipartite Graphs with an Application to Constraint Programming [PDF]

, 2011
The NP-hard general factor problem asks, given a graph and for each vertex a list of integers, whether the graph has a spanning subgraph where each vertex has a degree that belongs to its assigned list. The problem remains NP-hard even if the given graph
Abtg Wissensbasierte Systeme, Anders Yeo, Anders Yeo, Arezou Soleimanfallah, Eun Jung, Eun Jung Kim, Gregory Gutin, Gregory Gutin, Kim Arezou Soleimanfallah, Stefan Szeider, Stefan Szeider   +10 more
core   +1 more source