Results 121 to 130 of about 5,970,576 (296)

Fixed Point Results in Convex Double-Controlled Metric-Type Spaces and Applications

open access: yesMathematics
This paper investigates fixed point results in convex double-controlled metric-type spaces. By introducing a convex structure on double-controlled metric-type spaces, we study the convergence of the Mann iteration process for contractive mappings in this
Nazli Kadioglu Karaca
doaj   +1 more source

Time and nodal decomposition with implicit non-anticipativity constraints in dynamic portfolio optimization [PDF]

open access: yes
We propose a decomposition method for the solution of a dynamic portfolio optimization problem which fits the formulation of a multistage stochastic programming problem.
Elio Canestrelli, Diana Barro
core  

Fixed point theorems for set-valued contraction type maps in metric spaces

open access: yes, 2010
We first give some fixed point results for set-valued self-map contractions in complete metric spaces. Then we derive a fixed point theorem for nonself set-valued contractions which are metrically inward. Our results generalize many well-known results in
Amini-Harandi, A, O'Regan, D
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

open access: yesFEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay   +2 more
wiley   +1 more source

Composition analysis of large samples with PGNAA using a fixed point iteration.

open access: yes, 2002
The composition problem in large sample prompt gamma neutron activation analysis (PGNAA) is a nonlinear inverse problem. The basic form of the nonlinear inverse composition problem is presented.
Akkurt, Hatice
core   +3 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Existence and Uniqueness of a Fixed Point for the Bellman Operator in Deterministic Dynamic Programming [PDF]

open access: yes
We study existence and uniqueness of a fixed point for the Bellman operator in deterministic dynamic programming. We show that removing many of the assumptions of the theorem on the Bellman operator recently shown by Martins-da-Rocha and Vailakis ...
Takashi Kamihigashi
core  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

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