Results 61 to 70 of about 981,053 (295)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Input-to-state stability for discrete-time time-varying systems with applications to robust stabilization of systems in power form [PDF]

, 2005
Input-to-state stability (ISS) of a parameterized family of discrete-time time-varying nonlinear systems is investigated. A converse Lyapunov theorem for such systems is developed.
Laila, D. S., Astolfi, A.,, Nesic, Dragan, Laila, Dina Shona, Astolfi, A., Laila, Dina Shona,   +5 more
core   +1 more source

Essay on robust prescribed-time stabilization

Journal of Automation and Intelligence
As well-known, prescribed-time stabilizing design faces the need of using time-varying high gains which escape to infinity as time approaches the desired instant.
Yury Orlov
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Asymptotic stability for neural networks with mixed time-delays: The discrete-time case

, 2009
This is the post print version of the article. The official published version can be obtained from the link - Copyright 2009 Elsevier LtdThis paper is concerned with the stability analysis problem for a new class of discrete-time recurrent neural ...
Liu, Y, Liu, X, Wang, Z, Liu, Xiaohui., Wang, Zidong., Yurong Liu (9814022), Z Wang (81545), X Liu (7756691), Liu, Yurong.   +8 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Novel Fixed-Time Nonsingular Fast Terminal Sliding Mode Control for Second-Order Uncertain Systems Based on Adaptive Disturbance Observer

IEEE Access, 2020
In this paper, a novel fixed-time nonsingular fast terminal sliding mode control incorporating with an adaptive disturbance observer is proposed for second-order uncertain nonlinear systems to achieve fast stabilization and robust control.
Huihui Pan, Guangming Zhang, Huimin Ouyang, Lei Mei   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source