Results 31 to 40 of about 24,603 (266)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

THE ESSENCE OF FIXED ASSETS AS PROPERTY ACCOUNTING

open access: yesВестник университета, 2019
The problem of determining the substance and content of the concept of fixed assets. The different point of view of Russian and foreign scientists to the economic nature of the category «fixed assets». Given the author's definition of «fixed assets».
T. Rogulenko, E. Egorova
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

THE ESSENCE OF FIXED ASSETS AS PROPERTY ACCOUNTING

open access: yesВестник университета, 2017
The problem of determining the substance and content of the concept of fixed assets. The different point of view of Russian and foreign scientists to the economic nature of the category «fixed assets». Given the author's definition of «fixed assets».
T. Rogulenko, E. Egorova
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

FINANCING OF FIXED ASSETS AS OBJECT OF STATISTICAL RESEARCH

open access: yesСтатистика и экономика, 2016
Statistical analysis of fixed assets as the most valuable component of national wealth is relevant not only to solve traditional problems associated with the assessment of the availability, structure and dynamics of economic assets.
Dmitry V. Dianov, Nikolay V. Gaifulin
doaj   +1 more source

Rules of Fixed Assets Accounting Should Be Changed

open access: yesУчёт. Анализ. Аудит, 2020
Nowadays the role of accounting in managing the economy of businesses is increasing. Accounting is one of the main information sources for making managerial decisions in organizations.
V. G. Get’man
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

THE ANALYSIS OF SOME INDICATORS OF FIXED ASSET REPRODUCTION MANAGMENT ASSESMENT

open access: yesВестник Кемеровского государственного университета, 2014
The paper analyses of certain indicators for assessment of fixed asset reproduction scale and intensity. An interpretation of the values taken by each of this indicators is given in order to identify standards of fixed assets reproduction.
A. S. Matievich
doaj  

ENSURING FINANCIAL SECURITY IN RUSSIA’S NORTH AND ARCTIC REGIONS THROUGH FIXED ASSETS MANAGEMENT

open access: yesСевер и рынок: формирование экономического порядка, 2023
This study explores the management of fixed assets in the context of ensuring financial security for sustainable development in the North and Arctic regions of Russia.
Dmitriy S. Krapivin
doaj   +1 more source

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