Results 161 to 170 of about 2,125,440 (312)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Determinants of polydoctoring among patients with multimorbidity: a Nationwide Longitudinal Fixed-Effects Study in Japan. [PDF]

Fam Med Community Health
Ando T, Jani BD, Haruta J, Goto R.
europepmc   +1 more source

Fixed-effects inference and tests of correlation for longitudinal functional data. [PDF]

Stat Med, 2022
Li R, Xiao L, Smirnova E, Cui E, Leroux A, Crainiceanu CM.   +5 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The protective effect of housing affordability on childhood asthma risk: a longitudinal fixed-effects analysis. [PDF]

Am J Epidemiol
Li Y, Singh A, Bentley R.
europepmc   +1 more source

Comparing Two-way Fixed Effects and New Estimators for Difference-in-Differences: A Simulation Study and Empirical Example. [PDF]

Epidemiology, 2023
Goin DE, Riddell CA.
europepmc   +1 more source

A Fixed-Effects Analysis of How Income Inequality in a Municipality Affects Individual Mortality in Norway [PDF]

There is still much uncertainty about the impact of income inequality on health and mortality. Some studies have supported the original hypothesis about adverse effects, while others have shown no effects, and a few even indicated beneficial effects.
Kravdal, Øystein
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The applicability to systematic reviews of common effect, random effects and fixed effects approaches to meta-analysis. [PDF]

Stat Methods Med Res
Stevens RJ.
europepmc   +1 more source

Fixed-term employees in Australia: incidence and characteristics [PDF]

This paper presents an analysis of fixed-term employment in Australia or 3.3 per cent of employed persons in 2000. It finds that fixed-term employees are largely concentrated in Education (30 per cent of fixed- term employees in August 1998), Health and ...
Lou Will, Matthew Waite
core