Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Effects of differential contacts with the criminal legal system on mental health outcomes of adolescents and young adults: A fixed-effects model. [PDF]
PLoS OneOliveira RV, Culatta E.
europepmc +1 more source
Effects of education and age on the experience of youth violence in a very low-resource setting: a fixed-effects analysis in rural Burkina Faso. [PDF]
BMJ Open, 2023 Kuunibe N +5 more
europepmc +1 more source
Fixed Effects and Variance Components Estimation in Three-Level Meta-Analysis [PDF]
Meta-analytic methods have been widely applied to education, medicine, and the social sciences. Much of meta-analytic data are hierarchically structured since effect size estimates are nested within studies, and in turn studies can be nested within level-
Konstantopoulos, Spyros
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Visualizing heterogeneous associations: economic capital and adolescent football participation in China: a cross-sectional study using quantile regression with school-level fixed effects. [PDF]
Front PsycholJin D, Quan Z, Pang D, Li N.
europepmc +1 more source
Welfare effects of fixed and percentage-expressed child support awards [PDF]
Over the last decade a large number of states have significantly altered their legal statutes concerning the disposition of divorce cases involving children. In particular, many states have increasingly employed percentage-expressed orders in which child
D. Del Boca, C. J. Flinn
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Capybara: Efficient estimation of generalized linear models with high-dimensional fixed effects. [PDF]
PLoS OneSepulveda MV.
europepmc +1 more source
Effect of social activities on health checkups and recommended doctor visits: a fixed-effects analysis in Japan. [PDF]
Ind Health, 2023 Oshio T, Sugiyama K, Ashida T.
europepmc +1 more source