Results 61 to 70 of about 5,516,012 (291)
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source
Intuitionistic fixed point theories over Heyting arithmetic [PDF]
, 2010 In this paper we show that an intuitionistic theory for fixed points is conservative over the Heyting arithmetic with respect to a certain class of formulas. This extends partly the result of mine.
Arai, Toshiyasu
core
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
A logic with temporally accessible iteration [PDF]
, 2008 Deficiency in expressive power of the first-order logic has led to developing its numerous extensions by fixed point operators, such as Least Fixed-Point (LFP), inflationary fixed-point (IFP), partial fixed-point (PFP), etc.
Lisitsa, Alexei
core +2 more sources
Fixed points and proximate fixed points [PDF]
Fundamenta Mathematicae, 1968 T. B. Muenzenherger, R. E. Smithson
openaire +3 more sources
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Communications, Faculty Of Science, University of Ankara Series A1Mathematics and Statistics, 1984 The authors' main result is the following: Let (X,d) be a complete metric space and \(f: X\to X\) a self-mapping. If for x,y\(\in X\) and \(p>0\) the inequality \[ d(T^{2p}x,T^{2p}y)\leq a_ 1d(T^ px,T^{2p}x)+a_ 2d(T^ py,T^{2p}y)+a_ 3d(T^ px,T^ py) \] with \(a_ 1,a_ 2,a_ 3\geq 0\) and \(a_ 1+a_ 2+a_ ...
M. D. Khan, M. S. Khan
openaire +3 more sources
FEBS Letters, EarlyView.Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield +3 more
wiley +1 more source
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
Inventiones Mathematicae, 1984 For a self-map f of a compact connected polyhedron X the Nielsen number N(f) of f is defined to be the number of essential fixed point classes of f. N(f) is a lower bound for the number of fixed points of every map homotopic to f. This lower bound is known to be realizable if X has no local separating points and X is not a surface (closed or with ...
openaire +2 more sources