Results 141 to 150 of about 1,117,756 (300)

Nonlinear approximation of an ACQ-functional equation in nan-spaces

Fixed Point Theory and Applications, 2011
In this paper, using the fixed point and direct methods, we prove the generalized Hyers-Ulam stability of an additive-cubic-quartic functional equation in NAN-spaces. Mathematics Subject Classification (2010) 39B52·47H10·26E30·46S10·
Lee Jung, Park Choonkil, Azadi Kenary Hassan   +2 more
doaj  

Approximate Fixed Point Theorems in Banach Spaces with Applications in Game Theory

In this paper some new approximate fixed point theorems for multifunctions in Banach spaces are presented and a method is developed indicating how to use approximate fixed point theorems in proving the existence of approximate Nash equilibria for non ...
Brânzei, R., Tijs, S.H., Scalzo, V., Morgan, J.   +3 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

An investigation of two behavioural economic approaches to evaluating reinforcer value

, 2010
This study compares two approaches for comparing the value of two different reinforcers. The own-price demand method compares the changes in consumption of the reinforcers resulting from increases in the number of responses required to gain access to the
Lim, Bee Lan Linda
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

An Study on Real-time Efficiency optimization control Method of the IPMSM Drive systems

四川大学学报. 自然科学版, 2016
This paper proposes a method based on the quadratic programming (QP) sequence for solving optimization current , which ensure the minimal operation loss of the motor, of control system for interior permanent magnet synchronous motor (IPMSM) for electric ...
WU Qin-Mu, ZONG Ren-Jun, WANG Lin-Lin, CHEN Xiang-Ping, LUO Xue-Mei   +4 more
doaj  

Time and nodal decomposition with implicit non-anticipativity constraints in dynamic portfolio optimization [PDF]

We propose a decomposition method for the solution of a dynamic portfolio optimization problem which fits the formulation of a multistage stochastic programming problem.
Elio Canestrelli, Diana Barro
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source