Results 121 to 130 of about 16,609,354 (299)

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Fixed point theorems via Nash Equilibria [PDF]

open access: yes
In this note we show that the fixed points of a continuous function (or of an upper semi-continuous correspondence, with non-empty and convex values) can be attained as Nash Equilibria of a game with finitely many players.
Juan Pablo Torres-Martínez
core  

A new approach to the Assad-Kirk fixed point theorem

open access: yes, 2016
Altun, Ishak/0000-0002-7967-0554; MINAK, GULHAN/0000-0002-3711-9633In the present paper, considering the Wardowski's technique, we give a new approach to the Assad-Kirk fixed point theorem on metrically convex metric spaces.
Olgun, Murat   +2 more
core   +1 more source

Fixed points of Oslike contraction mapping: stability and convergence of a new iteration method

open access: yesApplied General Topology
This work introduces a novel three-type iteration method for estimating the fixed point approximation for a contraction mapping in the context of Banach space.
J. Grace Margrate Mary, R. Uthayakumar
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Fixed point theory for cyclic (ϕ - ψ)-contractions

open access: yes, 2011
In this article, the concept of cyclic (φ - ψ)-contraction and a fixed point theorem for this type of mappings in the context of complete metric spaces have been presented.
Sadarangani, Kishin   +3 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

A common fixed point for weak øcontractions on b-metric spaces

open access: yes, 2012
In this paper, we give a common fixed point result for single-valued and multi-valued mappings satisfying a weak Øcontraction in b-metric spaces. Presented theorems extend, generalize and improve some existing results in the literature. Some examples are
Aydi,H.   +3 more
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

ITERATIVE METHODS FOR APPROXIMATION OF FIXED POINTS AND THEIR APPLICATIONS

open access: yesJournal of the Operations Research Society of Japan, 2000
Summary: We deal with iterative methods for approximation of fixed points and their applications. We first discuss fixed point theorems for a nonexpansive mapping or a family of nonexpansive mappings. In particular, we state a fixed point theorem which answered affirmatively a problem posed during the Conference on Fixed Point Theory and Applications ...
openaire   +2 more sources

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