Results 191 to 200 of about 1,117,756 (300)

Comparing Dynamical Models Through Diffeomorphic Vector Field Alignment. [PDF]

Neural Comput
Chen R, Vedovati G, Braver T, Ching S.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

An Adaptive Octile JPS and Fuzzy-DWA Fused Path Planning Algorithm for Indoor Home Environments. [PDF]

Sensors (Basel)
Li W, Jia Z, Sun D, Han D, Qin Z, Liu Q.
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Rotation-tolerant representations elucidate the time-course of high-level object processing. [PDF]

PLoS One
Moerel D, Grootswagers T, Robinson AK, Engeler P, Holcombe AO, Carlson TA.   +5 more
europepmc   +1 more source

Properties of a fixed point method.

, 1999
A general pseudo-Bayes Fixed Point method for making inference about parameters of statistical models is recalled. The Fixed Point estimates are actually pseudo-Bayes in that they depend on a prior parametric class of densities rather than a particular choice for prior. Different from maximum likelihood, they take into account the full structure of the
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A General Finite Beam on Tensionless Foundation Model for Rail Track Characterization and Evaluation. [PDF]

Sensors (Basel)
Alshallaqi HH, Story BA.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Novel iterative method for the approximation of fixed point of a class of generalized ([Formula: see text])-nonexpansive mapping with applications to seir epidemic model. [PDF]

Sci Rep
Alharthi NH, Okeke GA, Udo AV, Alqahtani RT, Yusuf A.   +4 more
europepmc   +1 more source