Results 81 to 90 of about 1,062,749 (259)

A New Extragradient-Viscosity Method for a Variational Inequality, an Equilibrium Problem, and a Fixed Point Problem

Mathematics
In this research article, we introduce a novel iterative approach that builds upon a two-step extragradient-viscosity method. This method aims to find a common element among the solution set of a variational inequality, an equilibrium problem, and the ...
Maryam Yazdi, Saeed Hashemi Sababe
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Analytic and empirical study of the rate of convergence of some iterative methods

Journal of Numerical Analysis and Approximation Theory, 2015
We study analytically and empirically the rate of convergence of two \(k\)-step fixed point iterative methods in the family of methods \[ x_{n+1}=T(x_{i_0+n-k+1},x_{i_1+n-k+1},\dots, x_{{i_{k-1}+n-k+1}}),\,n\geq k-1, \] where \(T\colon X^k\rightarrow ...
Vasile Berinde, Abdul Rahim Khan, Mădălina Păcurar   +2 more
doaj   +2 more sources

Efficient Fixed-Point Method with Application to a Fractional Blood Flow Model

Fractal and Fractional
This paper introduces two generalized frameworks, the extended bipolar parametric b-metricspace (EBPbMS) and the extended bipolar fuzzy b-metric space (EBFbMS), which unify and extend several existing bipolar and fuzzy metric structures.
Nawal Alharbi, Nawab Hussain, Hamed Alsulami   +2 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Orthogonal stability of the generalized quadratic functional equations in the sense of Rätz

Demonstratio Mathematica, 2019
Let (X, ⊥) be an orthogonality module in the sense of Rätz over a unital Banach algebra A and Y be a real Banach module over A. In this paper, we apply the alternative fixed point theorem for proving the Hyers-Ulam stability of the orthogonally ...
Aiemsomboon Laddawan, Sintunavarat Wutiphol   +1 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Fixed points of Oslike contraction mapping: stability and convergence of a new iteration method

Applied General Topology
This work introduces a novel three-type iteration method for estimating the fixed point approximation for a contraction mapping in the context of Banach space.
J. Grace Margrate Mary, R. Uthayakumar
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source