Results 51 to 60 of about 3,309,531 (289)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Critical Theory of Non-Fermi Liquid Fixed Point in Multipolar Kondo Problem

Physical Review X, 2020
When the ground state of a localized ion is a non-Kramers doublet, such localized ions may carry multipolar moments. For example, Pr^{3+} ions in a cubic environment would possess quadrupolar and octupolar, but no magnetic dipole, moments.
Adarsh S. Patri, Yong Baek Kim
doaj   +1 more source

The plane fixed point problem

, 2008
In this paper we present proofs of basic results, including those developed so far by H. Bell, for the plane fixed point problem. Some of these results had been announced much earlier by Bell but without accessible proofs. We define the concept of the variation of a map on a simple closed curve and relate it to the index of the map on that curve: Index
Fokkink, Robbert J., Mayer, John C., Oversteegen, Lex G., Tymchatyn, E. D.   +3 more
openaire   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

New Existence Results for Fixed Point Problem and Minimization Problem in Compact Metric Spaces

Abstract and Applied Analysis, 2014
We first present some new existence theorems for fixed point problem and minimization problem in compact metric spaces without assuming that mappings possess convexity property.
Weng-Seng Heng, Wei-Shih Du, Chi-Lin Yen
doaj   +1 more source

SWATI: Synthesizing Wordlengths Automatically Using Testing and Induction [PDF]

, 2013
In this paper, we present an automated technique SWATI: Synthesizing Wordlengths Automatically Using Testing and Induction, which uses a combination of Nelder-Mead optimization based testing, and induction from examples to automatically synthesize ...
Jha, Susmit, Seshia, Sanjit A.
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Iterative Algorithms for the Split Problem and Its Convergence Analysis

Abstract and Applied Analysis, 2014
Now, it is known that the split common fixed point problem is a generalization of the split feasibility problem and of the convex feasibility problem. In this paper, the split common fixed point problem associated with the pseudocontractions is studied ...
Zhangsong Yao, Arif Rafiq, Shin Min Kang, Li-Jun Zhu   +3 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Application of Fixed-Point Theory for a Nonlinear Fractional Three-Point Boundary-Value Problem

Mathematics, 2019
Throughout this paper, via the Schauder fixed-point theorem, a generalization of Krasnoselskii’s fixed-point theorem in a cone, as well as some inequalities relevant to Green’s function, we study the existence of positive solutions of a ...
Ehsan Pourhadi, Reza Saadati, Sotiris K. Ntouyas   +2 more
doaj   +1 more source