Results 61 to 70 of about 429,862 (310)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

On solutions of inclusion problems and fixed point problems [PDF]

Fixed Point Theory and Applications, 2013
The paper proposes an iterative algorithm for the solution of the following problem: \[ x= S(x) \text{ and } x\in (A+B)^{-1}(0), \] where \(S:C\to C\) is a mapping and \(A,B:C\to H\) are two monotone mappings on a nonempty, closed, convex subset \(C\) of an Hilbert space \(H\).
openaire   +2 more sources

Infinite groups with fixed point properties

, 2007
We construct finitely generated groups with strong fixed point properties. Let Xac be the class of Hausdorff spaces of finite covering dimension which are mod–p acyclic for at least one prime p.
G. Arzhantseva, T. Januszkiewicz, Arzhantseva, Goulnara, I. J. Leary, Minasyan, Ashot, A. Minasyan, Bridson, MR, Januszkiewicz, T, J. Świa̧tkowski, Bridson, Martin R., Leary, IJ, Swiatkowski, J, Bridson, Martin Robert, Ian J Leary, Martin R Bridson, ASHOT MINASYAN, JACEK ŚWIA̧TKOWSKI, et al., Januszkiewicz, Tadeusz, Leary, Ian J., Bridson, Martin, Arzhantseva, Goulnara N., Minasyan, A, Swiatkowski, Jacek, Arzhantseva, G, M. R. Bridson   +23 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Random Function Iterations for Stochastic Fixed Point Problems

, 2023
We study the convergence of random function iterations for finding an invariant measure of the corresponding Markov operator. We call the problem of finding such an invariant measure the stochastic fixed point problem.
Hermer, Neal, Luke, D. Russell, Sturm, Anja   +2 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Iterative Algorithms for the Split Problem and Its Convergence Analysis

Abstract and Applied Analysis, 2014
Now, it is known that the split common fixed point problem is a generalization of the split feasibility problem and of the convex feasibility problem. In this paper, the split common fixed point problem associated with the pseudocontractions is studied ...
Zhangsong Yao, Arif Rafiq, Shin Min Kang, Li-Jun Zhu   +3 more
doaj   +1 more source

An approximate fixed point result for multivalued mappings under two constraint inequalities

, 2017
We consider an approximate multivalued fixed point problem under two constraint inequalities, for which we provide sufficient conditions for the existence of at least one solution.
VETRO, Francesca, Samet, B., VETRO, Calogero   +2 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Application of Fixed-Point Theory for a Nonlinear Fractional Three-Point Boundary-Value Problem

Mathematics, 2019
Throughout this paper, via the Schauder fixed-point theorem, a generalization of Krasnoselskii’s fixed-point theorem in a cone, as well as some inequalities relevant to Green’s function, we study the existence of positive solutions of a ...
Ehsan Pourhadi, Reza Saadati, Sotiris K. Ntouyas   +2 more
doaj   +1 more source