Results 171 to 180 of about 7,647,352 (298)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Charm Production in Fixed Target Experiments with Hadron and Photo Beams.

open access: yes, 1997
REVIEW OF EXPERIMENTAL DATA COLLECTED IN FIXED TARGET CHARM EXPERIMENTS WITH HADRON AND PHOTON ...
RATTI, SERGIO PEPPINO
core  

Illuminating Light Dark Matter with Fixed-Target Experiments

open access: yes
Astronomical and cosmological observations provide overwhelming evidence for a non-luminous matter component — dark matter (DM) — whose particle nature remains unknown.
Taylor Gray
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

D-wave heavy quarkonium production in fixed target experiments

open access: yes, 1999
We calculate the D-wave heavy quarkonium production at fixed target experiments under the NRQCD factorization formalism. We find that the color-octet contributions are two orders of magnitude larger than color-singlet contributions if color-octet matrix ...
Yuan, F, Qiao, CF, Chao, KT
core  

A simple and practical approach for protein serial crystallography using grease matrix and large-area support film. [PDF]

open access: yesJ Synchrotron Radiat
Sugahara M   +11 more
europepmc   +1 more source

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