Results 1 to 10 of about 1,567 (107)

The NAMPT Inhibitor FK866 in Combination with Cisplatin Reduces Cholangiocarcinoma Cells Growth

Cells, 2023
It is well established that Cholangiocarcioma (CCA) drug resistance plays a crucial role in the spread and survival of cancer cells.
Estanislao Peixoto, Brunella Franco, Lewis R. Roberts   +2 more
exaly   +3 more sources

The nicotinamide phosphoribosyltransferase inhibitor FK866 restricts influenza A virus replication by perturbing viral polymerase activity [PDF]

Journal of Virology
Nicotinamide phosphoribosyltransferase (NAMPT), a key rate-limiting enzyme in NAD+ synthesis, plays important roles in various physiological and pathological processes.
Changjie Lv, Shuang Wang, Mingyue Song, Jianmei Wu, Wanxin Wei, Guijie Guo   +5 more
doaj   +2 more sources

Inhibiting Nampt signaling promotes M2 macrophage polarization to enhance bone regeneration in periodontitis [PDF]

Frontiers in Bioengineering and Biotechnology
BackgroundDysregulated macrophage polarization is a fundamental cause of bone loss in periodontitis. However, the role of nicotinamide phosphoribosyltransferase (NAMPT) in macrophage regulation within periodontitis remains unclear.
Yixin Xia, Kexin Xie, Chunhui Liao, Zhanyi Ye, Baojun Long   +4 more
doaj   +2 more sources

Hydrogen Sulfide Protects Against Cerebral Ischemia–Reperfusion Injury in Rats via S-Sulfhydrating NAMPT to Enhance Mitochondrial Function and Autophagy in Cerebrovascular Endothelial Cells [PDF]

Pharmaceuticals
Objective: Cerebral ischemia–reperfusion (I/R) injury constitutes a pivotal pathological driver in cerebrovascular disorders such as stroke, yet effective therapeutic interventions remain scarce.
La Jiang, Shuai Liang, Yu Jiang, Jia-Rong Jiang, Shan Wang, Xiaojiao Yin, Zhiwu Chen, Ji-Yue Wen, Shuo Chen   +8 more
doaj   +2 more sources

Aerobic exercise combined with FK866 ameliorates Alzheimer’s disease-like pathology in APP/PS1 mice with NAMPT abnormality [PDF]

Frontiers in Immunology
Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the NAD+ salvage pathway, has emerged as an important regulatory node linking metabolic homeostasis to neuroinflammatory responses.
Chang Sun, Tinggui Zhang, Bei Fan, Xianliang Zhang, Na Zhao   +4 more
doaj   +2 more sources

NAMPT activity plays a key role in driving autoimmune processes that mediate beta-cell death and type 1 diabetes development in mice [PDF]

Cell Death and Disease
Type 1 diabetes (T1D) is characterised by destruction of pancreatic beta-cells by islet-infiltrating cytotoxic lymphocytes and elevated intra-islet secretion of pro-inflammatory cytokines.
Daniel Egbase, Sophie R. Sayers, Naila Haq, Vesela S. Gesheva, Jithu J. Varghese, Sreya Bhattacharya, Jay Kynaston, Ella L. Hubber, Lorna I. F. Smith, Timothy J. Pullen, Henry Gerdes, Vivian K. Lee, David Hopkins, Min Zhao, Yee Cheah, Joshua Greally, Sam Butterworth, James A. Pearson, Gavin A. Bewick, Shanta J. Persaud, Paul W. Caton   +20 more
doaj   +3 more sources

RAS/PI3K pathway mutations sensitise epithelial ovarian cancer cells to a PARP/NAMPT inhibitor combination [PDF]

Communications Biology
The combination of PARP and NAMPT inhibitors (PARPi/NAMPTi) has been explored for the treatment of triple-negative breast cancer, Ewing sarcoma and high-grade serous carcinoma (HGSC). However, dose limiting toxicity has hampered NAMPTi in clinical trials.
Michael Gruet, Yitao Xu, Lyutong An, Yurui Ma, Cristina Balcells, Katie Tyson, Laila C. Evangelista, Sarah Spear, Yuewei Xu, Flora McKinney, Julia Babuta, Chandler Bray, Chiharu Wickremesinghe, Alexandros P. Siskos, Anke M. Nijhuis, Edward W. Tate, Iain A. McNeish, Adrian Benito, Hector C. Keun   +18 more
doaj   +2 more sources

ROS‐Responsive Hydrogel for Localized Delivery of Nampt and Stat3 Inhibitors Exhibits Synergistic Antitumor Effects in Colorectal Cancer Through Ferroptosis Induction and Immune Microenvironment Remodeling [PDF]

Advanced Science
Targeting Nampt to modulate NAD+ metabolism and exert antitumor effects has become a research hotspot in the field of cancer metabolism. But early clinical trials have only achieved modest results, primarily due to the need for improved efficacy and the ...
Chenyang Ye, Mi Mi, Saimeng Shi, Lina Qi, Shanshan Weng, Lu Wang, Yier Lu, Chao Chen, Yinuo Tan, Mengyuan Yang, Cheng Guo, Rui Bai, Xuefeng Fang, Ji Wang, Ying Yuan   +14 more
doaj   +2 more sources

Targeting iNAMPT and NAD Biosynthesis to Break the Obesity-Associated Liver Cancer Link [PDF]

Biomedicines
Background and Objectives: Obesity is linked to liver cancer through metabolic mechanisms and can promote tumor growth through metabolic impairment, decreased lipid metabolism, and interference of the energy balance in the liver.
Kelly Thornton, Linda Torres, Elisa L. Pedone, Jessica S. Waltenbaugh, Cassandra M. Swanson, Emily Gonzalez, Ramona S. Price   +6 more
doaj   +2 more sources

The Fluorinated NAD Precursors Enhance FK866 Cytotoxicity by Activating SARM1 in Glioblastoma Cells

Biology
Glioblastoma, a formidable brain tumor characterized by dysregulated NAD metabolism, poses a significant therapeutic challenge. The NAMPT inhibitor FK866, which induces NAD depletion, has shown promise in controlling tumor proliferation and modifying the
Yong Juan Zhao, Wanhua Li, Wei Ming He
exaly   +3 more sources