FK866 Protects Human Dental Pulp Cells against Oxidative Stress-Induced Cellular Senescence [PDF]
Antioxidants, 2021 FK866 possesses various functional properties, such as anti-angiogenic, anti-cancer, and anti-inflammatory activities. We previously demonstrated that premature senescence of human dental pulp cells (hDPCs) was induced by hydrogen peroxide (H2O2).
Chang Youp Ok +6 more
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The NAMPT inhibitor FK866 reverts the damage in spinal cord injury [PDF]
Journal of Neuroinflammation, 2012 Background Emerging data implicate nicotinamide phosphoribosyl transferase (NAMPT) in the pathogenesis of cancer and inflammation. NAMPT inhibitors have proven beneficial in inflammatory animal models of arthritis and endotoxic shock as well as in ...
Esposito Emanuela +8 more
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Synthesis and Evaluation of Reactive Oxygen Species Sensitive Prodrugs of a NAMPT Inhibitor FK866
Molecules, 2022 NAMPT is an attractive target in cancer therapy and numerous NAMPT inhibitors have been developed. However, the clinical activities of NAMPT inhibitors have displayed disappointing results in clinical trials for their dose-limiting toxicities.
Zili Xu +4 more
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Drug Design, Development and Therapy, 2017 Peixin Huang,1 Mark W Lee Jr,2 Keivan Sadrerafi,2 Daniel P Heruth,1 Li Q Zhang,1 Dev Maulik,3,4 Shui Qing Ye1,4 1Division of Experimental and Translational Genetics, Department of Pediatrics, The Children’s Mercy Hospital, University of Missouri ...
Huang P +6 more
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NAD depletion by FK866 induces autophagy [PDF]
Autophagy, 2008 : NAD is a multifunctional molecule involved in both metabolic processes and signaling pathways. Such signalling pathways consume NAD which is replenished via one of several biosynthesis pathways. We show that influx of NAD across the plasma membrane may
Condorelli F. +3 more
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Identification of new FK866 analogues with potent anticancer activity against pancreatic cancer [PDF]
European Journal of Medicinal Chemistry, 2022 Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal diseases for which chemotherapy has not been very successful yet. FK866 ((E)-N-(4-(1-benzoylpiperidin-4 yl)butyl)- 3-(pyridin-3-yl)acrylamide) is a well-known NAMPT (nicotinamide ...
Poty, Sophie +11 more
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FK866 attenuates acute hepatic failure through c-jun-N-terminal kinase (JNK)-dependent autophagy
Scientific Reports, 2017 FK866 exhibits a protective effect on D-galactosamine (GaIN)/lipopolysaccharide (LPS) and concanavalin A (ConA)-induced acute liver failure (ALF), but the mechanism by which FK866 affords this benefit has not yet been elucidated.
Enshuang Guo +8 more
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Neuroprotective effects of FK866 against traumatic brain injury: Involvement of p38/ERK pathway
Annals of Clinical and Translational Neurology, 2020 Objective FK866 is an inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), which exhibits neuroprotective effects in ischemic brain injury. However, in traumatic brain injury (TBI), the role and mechanism of FK866 remain unclear.
Zhongju Tan +4 more
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FK866-induced NAMPT inhibition activates AMPK and downregulates mTOR signaling in hepatocarcinoma cells [PDF]
Biochemical and Biophysical Research Communications, 2020 Background: Nicotinamide phosphoribosyltransferase (NAMPT) is the key enzyme of the NAD salvage pathway starting from nicotinamide. Cancer cells have an increased demand for NAD due to their high proliferation and DNA repair rate.
Penke, Melanie +6 more
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Characterisation of Pharmacological Mechanisms and Potential Therapeutic uses of FK866 [PDF]
, 2017 The finding that NAD+ plays a role in a variety of signalling pathways, including gene expression, Ca2+ signalling and DNA repair mechanisms, has sparked interest in the proteins involved in these pathways as potential pharmacological targets ...
Ferguson, Niketa
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